Xyzal Pathology

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Author:
NinaTolentino
ID:
270271
Filename:
Xyzal Pathology
Updated:
2014-04-12 09:55:12
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Xyzal
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AX PEE
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  1. It is the chronic disorder of the nasal mucosal membrane triggered by an inflammatory response following allergen exposure to the nose.
    Allergic Rhinitis
  2. It is caused by an allergic response to a harmful substance that an individual has become sensitized to, resulting from the recognition of the substance by IgE.
    Allergic Rhinitis
  3. What are 3 phase of Allergic Rhinitis?
    • A. Sensitization Period
    • B. Early Phase
    • C. Late phase
  4. ARIA classified AR to be intermittent if symptoms persists for?
    <4 days per week OR < 4weeks
  5. ARIA classified AR to be persistent if symptoms persists for?
    >4days /week AND >4weeks
  6. Give 3 Treatment Goals in managing AR.
    • a. To alleviate symptoms severity
    • b. To reduced the risk of developing associated disorders
    • c. To control underlying inflammation 
  7. TRUE OR FALSE
    ARIA recommends new generation over old generation oral antihistamines in patients with AR.
    TRUE
  8. TRUE OR FALSE
     ARIA 2010 suggest intranasal antihistamines vs new generation oral antihistamine in adults with AR
    • FALSE
    • ARIA suggest new generation OAH vs intranasal antihistamines
  9. TRUE OR FALSE
    ARIA 2010 suggests that clinicians do not administer and patients do not use intranasal antihistamines for persistent AR until more data are available.
    TRUE
  10. TRUE OR FALSE
    ARIA 2010 suggest LTRA VS OAH in SAR patients (conditional recommendation /moderate quality evidence)
    • FALSE
    • Suggest OAH vs LTRA
  11. TRUE OR FALSE
    ARIA 2010 suggest OAH VS LTRA in preschool children with PAR ( conditional recommendation /low quality evidence)
    TRUE
  12. What is the cells that INITIATES the allergic response?
    MAST CELLS
  13. It is the most important antibody in allergy that only becomes functional when it is bound to an immune effector cells such as mast cell.
    IgE
  14. It is a naturally occurring substance released by the mast cells after being exposed to a threatening foreign substance in the body or, in an allergic person, an allergen.
    HISTAMINES
  15. It is a common skin condition affecting up to 20% of individual at some time in their life. It involves only the superficial portion of the dermis. Transient in nature.
    URTICARIA
  16. It comes from the Latin word means sting. It is a cutaneous manifestation of localized, non pitting edema.
    URTICARIA
  17. A firm elevated swelling of the skin known in the medical terminology as a papule.
    WHEALS
  18. It is generally pale red in color, although color can also be deep red or purple;may be round, oval or irregular in shape and are usually rounded or flat topped.
    WHEALS
  19. Reddening of the skin spreading outward from a focus of infection or irritation.
    FLARES
  20. An itch or sensation that makes a person want to scratch. Can cause discomfort and can be frustrating. Can lead to sleeplessness, anxiety and depression.
    PRURITUS
  21. What are the 4 types of Urticaria?
    • A. CIU
    • B. Dermographism
    • C. Cold urticaria
    • D. Cholnergic urticaria
  22. What are the three class that causes urticaria?
    • A. Physical stimuli ( dermographism, cold, pressure, heat, solar, cholinergic)
    • B. Chemical stimuli ( food, food additives, drugs,toxin of plants and insects)
    • c. Infection (viral, bacterial, parasitic)
  23. What are the two types of urticaria according to duration of symptoms?
    • A. Acute urticaria - symptoms persist for less than 6weeks
    • B. Chronic urticaria - symptoms persist for more than 6weeks. Most cases are idiopathic ( up to 80%)
  24. What are the two types of urticaria according to origin of disease?
    • A. Non allergic urticaria 
    • B. Allergic urticaria
  25. What is the action of histamine on the blood vessels?
    Local vasodilation and edema
  26. What is the action of histamines on sensory nerves?
    Sensory nerve stimulation - Itch and flare
  27. Give 3 management of Urticaria.
    • A. Avoidance of triggers
    • B. Pharmacological treatment (antihistamines)
    • C. Adrenaline in case of anaphylaxis
  28. What is the treatment algorithm recommendation of urticaria?
    • 1. nsAH 
    • 2. nsAH updosing
    • 3. Add LTRA or change nsAH
    • 4. Add Cislosporon A, H2antihistamine, Dapsone Omalisumab
  29. What are the treatment option for CU?
    • nsAH
    • LTRA
    • sytemis steroid
    • cyclisporine, H2antihistamine, dapsone, Omalisumab

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