Thrombocytopenia is common in critically ill patients and is associated with increased mortality.
Up to 25% of critically ill patients will develop thrombocytopenia as a result of a medication, termed drug-induced thrombocytopenia (DIT).
Antibiotcs are a common, yet infrequently recognized, cause of DIT.
- Antibiotics reported to cause DIT:
In fact, piperacillin/tazobactam
has been associated with DIT more frequently than any other penicillin.
ReferencesPriziola JL, Smythe MA, Dager WE. Drug-induced thrombocytopenia in critically ill patients. Crit Care Med 2010; 38(S):S145-54.