Coxibs. Name two drugs. Selectivity COX1 or 2? Recommended use and why? Onset of action time for analgesia and anti-inflamation? Contraindications?
Selective COX-2, Lower risk of GI bleeding, no antiplatelet effect.
Low dose, for short duration if possible, risk of MI/stroke associated with long term tx. For patients who need NSAID but risk of GI toxicity.
Full analgesia 1 week, full antiinflammatory up to 3 weeks.
Ulcerative colitis, Crohn's disease - worsen bowel inflammation. Ischaemic heart disease, heart failure, vascular disease