Ch 18 Blood 3

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Author:
eddardofwinter
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270904
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Ch 18 Blood 3
Updated:
2014-04-20 20:27:28
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Bio
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  1. What are the two principle functions of Erythrocytes?
    • –Carry oxygen from lungs to cell tissues
    • –Pick up CO2 from tissues and bring to lungs
  2. Determined by surface glycoprotein and glycolipids
    Blood type
  3. _____ proteins (spectrin and actin) give membrane
    durability and resilience
    •Stretch and bend as squeezed
    through small capillaries
    Cytoskeletal
  4. 33% of cytoplasm is?
    Hemoglobin (Hb)
  5. ____ million hemoglobin molecules on one RBC
    280
  6. O2 delivery to _______  and CO2 transport to _______.
    tissue, lungs
  7. –Produces carbonic acid from CO2
    and water
    –Important role in gas transport and pH balance
    Carbonic anhydrase (CAH) in cytoplasm
  8. Each hemoglobin (Hb) molecule consists of?
    • –Four protein chains—globins
    • –Four heme groups
  9. –Nonprotein moiety that binds O2 to ferrous ion (Fe2+) at its center
    Heme groups
  10. –percentage of  whole blood volume composed of RBCs
    •Men 42% to 52% cells; women 37% to 48% cells
    Hematocrit (packed cell volume)
  11. •Men 13 to 18 g/dL; women 12 to 16 g/dL
    Hemoglobin concentration of whole blood
  12. •Men 4.6 to 6.2 million/mL; women 4.2 to 5.4 million/mL
    RBC count
  13. RBC values are lower in women because?
    • –Androgens stimulate RBC production
    • –Women have periodic menstrual losses
    • –Hematocrit is inversely proportional to percentage of body fat
  14. _____ million RBCs are produced per
    second
    2.5
  15. Average lifespan of a erythrocyte is?
    about 120 days
  16. Development of a erythrocyte takes
    • •3 to 5 days
    • –Reduction in cell size, increase in cell number, synthesis of hemoglobin, and loss of nucleus
  17. In the negative feedback controle of erythrocyte homeostasis a drop in RBC count causes?
    Kidney hypoxemia
  18. In the negative feedback controle of erythrocyte homeostasis kidney production of erythropoietin stimulates?
    Bone marrow
  19. In the negative feedback controle of erythrocyte homeostasis RBC count increases in __ to ___ days
    3 to 4
  20. What are the stimuli for increasing erythropoiesis?
    • –Low levels O2  (hypoxemia)
    • –High altitude
    • –Increase in exercise
    • –Loss of lung tissue in emphysema
  21. Erythrocyte Death and Disposal:

    RBCs lyse in narrow channels in the?
    Spleen

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