Ch 18 Blood 3
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What are the two principle functions of Erythrocytes?
- –Carry oxygen from lungs to cell tissues
- –Pick up CO2 from tissues and bring to lungs
Determined by surface glycoprotein and glycolipids
_____ proteins (spectrin and actin) give membrane
durability and resilience
•Stretch and bend as squeezed
through small capillaries
33% of cytoplasm is?
____ million hemoglobin molecules on one RBC
O2 delivery to _______ and CO2 transport to _______.
–Produces carbonic acid from CO2
–Important role in gas transport and pH balance
Carbonic anhydrase (CAH) in cytoplasm
Each hemoglobin (Hb) molecule consists of?
- –Four protein chains—globins
- –Four heme groups
–Nonprotein moiety that binds O2 to ferrous ion (Fe2+) at its center
–percentage of whole blood volume composed of RBCs
•Men 42% to 52% cells; women 37% to 48% cells
Hematocrit (packed cell volume)
•Men 13 to 18 g/dL; women 12 to 16 g/dL
Hemoglobin concentration of whole blood
•Men 4.6 to 6.2 million/mL; women 4.2 to 5.4 million/mL
RBC values are lower in women because?
- –Androgens stimulate RBC production
- –Women have periodic menstrual losses
- –Hematocrit is inversely proportional to percentage of body fat
_____ million RBCs are produced per
Average lifespan of a erythrocyte is?
about 120 days
Development of a erythrocyte takes
- •3 to 5 days
- –Reduction in cell size, increase in cell number, synthesis of hemoglobin, and loss of nucleus
In the negative feedback controle of erythrocyte homeostasis a drop in RBC count causes?
In the negative feedback controle of erythrocyte homeostasis kidney production of erythropoietin stimulates?
In the negative feedback controle of erythrocyte homeostasis RBC count increases in __ to ___ days
3 to 4
What are the stimuli for increasing erythropoiesis?
- –Low levels O2 (hypoxemia)
- –High altitude
- –Increase in exercise
- –Loss of lung tissue in emphysema
Erythrocyte Death and Disposal:
RBCs lyse in narrow channels in the?
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