Endo

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Author:
Neda317
ID:
271026
Filename:
Endo
Updated:
2014-04-18 21:32:15
Tags:
pharm
Folders:
pharm
Description:
endocrine
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  1. Lispro

    Aspart

    Glulisine
  2. Rapid acting Insulin
  3. Regular Insuline
    short acting SC/IV
  4. NPH


    Lente
    Intermediate Insuline
  5. Glargine

    Detemir

    Ultralente
    Long acting Insulin
  6. TX fo Hypoglycemia
    Glucagon, Dextrose , Diazoxide
  7. DOC insulinoma
    Diazoxide
  8. How you treat DKA?
    • IV Insulin(regular)  
    • IV fluids, Dextrose
    • Correct electrolytes, K+
  9. What are these counter regulatory
    hormones in hypoglycemia?
    • Glucagon
    • GH
    • Cortisol
    • Epi
  10. •Sulfonylureas
    Insulin secretagogues
  11. Glitinides
    Insulin secretagogues
  12. biguanides
    Insulin sensitizers
  13. Thiazolidinediones
    Insulin sensitizers
  14. Acarbose
    α-glucosidase inhibitors
  15. Miglitol
    α-glucosidase inhibitors
  16. Sitagliptin
    DPP-4 Inhibitors
  17. Saxagliptin
    DPP-4 Inhibitors
  18. Exenatide
    GLP-1 analogs
  19. Liraglutide
    GLP-1 analogs
  20. Pramlintide-
    Amylin analogs
  21. Tolbutamide
              Tolazamide
              Chlorpropramide
    Sulfonylureas first generation
  22. Glipizide
    Glyburide 

    Glimepiride
    Sulfonylureas second Generation
  23. •Repaglinide, Nateglinide (D-phenylalanine)
    Meglitinides
  24. Biguanides
    Metformin
  25. Pioglitazone & Rosiglitazone
    Thiazolidinediones
  26. •Inhibitor of α-glucosidase in the brush borders of small intestine & inhibits amylase
    • Acarbose
    • Miglitol
  27. EXENATIDE, Liraglutide
    • Glucagon
    • like polypeptide (GLP-1) agonist
  28. •Inhibitor
    of dipeptidyl peptidase-4 (DPP-4)
    • SITAGLIPTIN,
    • Saxagliptin
  29. Colesevelam
    • Bile
    • acid sequestrants
  30. •Somatropin  

    •Somatrem
    GH agonist
  31. Somatostatin (short t1/2)

    Octreotide (long t1/2)
    Growth hormone antagonists
  32. –Urofollitropin (uFSH)

    –follitropin alfa (rFSH)

    –follitropin beta (rFSH)
    Follicle-Stimulating Hormone
  33. –Lutropin (rLH)
    Luteinizing Hormone
  34. •Gonadorelin

    •goserelin, histrelin, leuprolide
    • Gonadotropin-releasing hormone & its
    • analogs
  35. •Ganirelix

    •cetrorelix
    GNRH Receptor antagonists
  36. •Bromocriptine

    •Cabergoline

    •Pergolide
    Dopamine agonists
  37. •Levothyroxine (T4)

    •Liothyronine (T3)

    •Liotrix
    Thyroid analog
  38. •Propylthiouracil
     
    •Methimazole
     
    •Carbimazole
    Antithyroid drugs: Thioamides
  39. •perchlorate (ClO4–),

    •pertechnetate (TcO4–)

    •thiocyanate (SCN–)
    Anion Inhibitors anti thyroid
  40. •diatrizoate

    •iohexol
    Iodine and Iodides anti thyroid
  41. Radioactive Iodine (131I)
    Anti thyroid
  42. •metoprolol, propranolol, atenolol
    Adrenoceptor-Blocking Agents for hyperthyroidism s/s
  43. 6.Radiation exposure and the thyroid

     tx?
    K iodide
  44. •Hydrocortisone (cortisol)  
    •Cortisone
    •Prednisone  
    •Prednisolone  
    • Methylprednisolone
    Glucocorticoids

    Short- to medium-acting glucocorticoids
  45. •Triamcinolone 

    •Paramethasone
    Glucocorticoids

    Intermediate-acting glucocorticoids
  46. •Betamethasone 

    •Dexamethasone
    • Glucocorticoids 
    • Long-acting glucocorticoids
  47. Fludrocortisone

    DesOxycortiCosterone
    Acetate
    Minerlocorticoids
  48. •Beclomethasone

    •Budesonide(spray for asthma or enema)

    •Fluticasone

    •Triamcinolone
    Topical steroid  preparations:
  49. •Metyrapone

    •Aminoglutethimide

    •Trilostane
    Antagonists of glucocorticoids
  50. Aminoglutethimide MOA and use?
    primarily inhibits CYP11A1  

    •Cushing's syndrome 

    •breast cancer
  51. Metyrapone MOA and use?
    selective inhibitor of CYP11B1 (11b-hydroxylase)

    •Usedin Cushing's syndrome

    •Hirsutism ,oedema are the adverse effects
  52. Trilostane MOA ?
    17 hydroxysteroid dehydrogenase inhibitor
  53. •Spironolactone

    •Eplerenone 

    •Drospirenone
    Antagonists of mineralocorticoids
  54. Spironolactone use?
    • •Used
    • in treatment of Primary hyperaldosteronism

    •Hirsutism
  55. methyltestosterone, fluoxymesterone
    17α-alkylated androgens:
  56. Testosterone enanthate,
    cypionate
    Esters
  57. Nandrolone     

    Oxymetholone

    Methenolone

    Oxandrolone
    ANABOLIC STEROIDS:
  58. Leuprolide, Histrelin

    Abarelix
    Antiandrogens
  59. Flutamide, &

    Bicalutamide
    Androgen  receptor antagonists
  60. Cyproterone acetate use?
    used in women to treat hirsutism

    in men to decrease excessive sexual drive
  61. Finasteride and Dutasteride MOA
    5 α-reductase inhibitor.

    Decreases prostatic dihydrotestosterone conc
  62. Finasteride use:
    •BPH.

    Male pattern baldness
  63. Clomiphene
    Antiestrogens
  64. Tamoxifen
    Raloxifene
    • Selective Estrogen Receptor Modulators
    • (SERMs)
  65. Raloxifene MOA
    Estrogen agonist in bone, liver.

    Antagonist in breast,endometrium
  66. Tamoxifen MOA
    • Estrogenic actions
    •  – bone,brain,liver

    • Antagonistic actions
    •  – breast
  67. Medroxy Progesterone Acetate (MPA),megestrol, nomegestrol
    Norethindrone
    Desogestrel
    Drospirenone
    Levonorgestre
    Synthetic progestins
  68. MIFEPRISTONE
    ANTIPROGESTIN
  69. •1 tab of  Levonorgestrel 0.75mg alone within 48 hrs, repeated after 12 hrs.
    •Single 600mg of mifepristone within 72 hrs.
    • 3.Postcoital (emergency)
    • contraception:

    • PLAN
    • B:
  70. Danazol
    suppression of Gn secretion               ¯

    • inhibition
    • of  testicular/ovarian function
  71. Teriparatide  (Forteo):
    recombinant PTH
  72. Calcitonin
    Actions:

    • bone:
    • inhibits osteoclastic bone resorption

    • Kidney:
    • Inhibits reabsorption of Ca & PO4
  73. etidronate, pamidronate, alendronate, risendronate
    Bisphosphonates
  74. Denusomab
    (Prolia): MOA and use
    • inhibits RANKL
    • Use: Osteoporosis and giant cell tumor of bone
  75. Cinacalcet MOA and use
    • activates
    • calcium sensing receptor on parathyroid gland - calcimimetic
    • Use: secondary hyperparathyroidism in chronic kidney disease 
    • Parathyroid carcinoma
  76. Plicamycin use:
    cytotoxic antibiotic

    Use: hypercalcemia

    • Paget’s
    • disease
  77. Gallium Nitrate use?
    Use: hypercalcemia

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