-
What is the MOA of ipilimumab (Yervoy)?
- Blocks the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) on T cells
- Inhibiting proliferation/differentiation of the immune cells
- T-cell mediated antitumor immune response is activated
-
What are the indications for ipilimumab (Yervoy)?
Metastatic melanoma, often used with dacarbazine.
-
What are the SE for ipilimumab (Yervoy)?
Immune mediated conditions (GI-enterocolitis, hepatitis, neuropathy, rash)
-
What is the MOA of Brentuximab vedotin (Adcetris)?
- Monoclonal antibody that binds CD30
- Linked to a microtubule disrupting agent, monomethyl auristatin E (MMAE) and a protease linker
- The antibody binds to CD30 and internalizes
- MMAE binds to tubulin
- Causes apoptosis and cell cycle arrest
-
What are the indication for brentuximab vedotin (Adcetris)?
- Hodgkin’s lymphoma
- after failure of autologous stem cell transplant (ASCT) or 2 prior multi-agent chemotherapy regimens
-
What are the SE for brentuximab vedotin (Adcetris)?
peripheral neuropathy, neutropenia, infusion reactions.
-
What are the Histone deactylase (HDAC) inhibitors?
vorinostat (Zolinza) and romidepsin (Istodax)
-
What is the Mechanism of action of vorinostat (Zolinza) and romidepsin (Istodax)?
- Histone deacetylase (HDAC) inhibitor thereby increasing acetylation of histones and regulatory proteins in the cell nucleus that help control DNA transcription.
- Acetylation increases gene transcription leading to cell-cycle arrest and apoptosis.
-
What is the indication for vorinostat (Zolinza) and romidepsin (Istodax)?
cutaneous T-cell lymphoma
-
What are the SE for vorinostat (Zolinza) and romidepsin (Istodax)?
GI, anemia, thrombocytopenia, pulmonary embolism
-
What are the Immunostimulants?
- Interferon alfa-2a (Roferon)
- Interferon alfa-2b (Intron)
- Aldesleukin
-
What is the MOA of Interferon alfa-2a (Roferon) Interferon alfa-2b (Intron)?
- Bind to cell surface receptors causing gene expressions that result in:
- Enhancement of host immune responses
- Direct antiproliferative effects on cancer cells
-
What is the brand name for Interferon alfa-2a?
Roferon
-
What is the brand name for Interferon alfa-2b?
Intron
-
What are the indications for vorinostat (Zolinza) and romidepsin (Istodax)?
- CML in combination with chemotherapy
- Hairy cell leukemia
- Malignant melanoma
- AIDS-related Kaposi’s sarcoma
- Non-Hodgkin’s lymphoma
- Hepatitis C and B
-
What are the adverse effects of vorinostat (Zolinza) and romidepsin (Istodax)?
Flu-like symptoms
-
What is EGFR (ErbB1) overexpressed?
- Non-small cell lung cancer;
- Head and neck cancer
- Colon cancer,
- Pancreatic cancer
-
What drugs can used to treat EGFR (ErbB1) receptor overexpression?
- gefitinib, erlotinib
- cetuximab, panitumumab
-
What is VEGFR-1,2 overexpressed?
Advanced renal cell carcinoma
-
What drugs can used to treat VEGFR-1,2 receptor overexpression?
sorafenib, sunitinib
-
What is VEGF ligand overexpressed?
Breast, colorectal, lung, malignant glioma, non-small cell lung cancer
-
What drugs can used to treat VEGF ligand receptor overexpression?
bevacizumab
-
What is HER-2/neu (ErbB2) overexpressed?
Breast cancer
-
What drugs can used to treat HER-2/neu (ErbB2) receptor overexpression?
-
What is PDGFR overexpressed?
Gastrointestinal stromal tumor (GIST)
-
What drugs can used to treat PDGFR receptor overexpression?
Sorafenib, sunitinib
-
What is FGFR3 overexpressed?
Multiple myeloma
-
What drugs can used to treat FGFR3 receptor overexpression?
thalidomide, lenalidomide (inhibiting
-
What is c-KIT overexpressed?
Gastrointestinal stromal tumor (GIST)
-
What drugs can used to treat c-KIT receptor overexpression?
imatinib
-
What is BCR-ABL overexpressed?
- Chronic myelogenous leukemia (CML)
- Acute promyelocytic leukemia (APL)
-
What drugs can used to treat BCR-ABL receptor overexpression causing APL?
imatinib
-
What drugs can used to treat BCR-ABL receptor overexpression causing APL?
Arsenic trioxide, tretinoin
-
What is asparaginase overexpressed?
Acute lymphocytic leukemia (ALL)
-
What drugs can used to treat asparaginase receptor overexpression?
asparaginase
-
What is CD30 antigen overexpressed?
Hodgkin’s Lymphoma
-
What drugs can used to treat CD30 receptor overexpression?
brentuximab vedotin
-
What is CD20 antigen overexpressed?
B-cell non-Hodgkin’s lymphoma (NHL)
-
What drugs can used to treat X receptor overexpression?
- rituximab
- ibritumomab tiuxetan
- tositumomab/131I-tositumomab
-
What is CD52 antigen overexpressed?
Chronic lymphocytic leukemia (CLL)
-
What drugs can used to treat CD52 antigen receptor overexpression?
alemtuzumab
-
What is PMS-RARα fusion protein overexpressed?
Acute promyelocytic leukemia
-
What drugs can used to treat PMS-RARα fusion protein receptor overexpression?
arsenic trioxide, tretinoin
|
|