Chapter 13 Immuno

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  1. Autoimmune diseases are more common for this gender.
  2. What type of tolerance mechanisms pertain to these?

    -Negative selection in the bone marrow and thymus.

    - Expression of tissue-specific proteins in the thymus.
    Central tolerance mechanisms
  3. What type of mechanism contributes to no lymphocyte access to some tissues?
    Immunologically privileged site
  4. What type of tolerance mechanisms pertain to these?

    -Suppression of autoimmune responses by regulatory T cells.

    -Induction of anergy in autoreactive B and T cells.
    Peripheral tolerance mechanisms
  5. What are the classically defined sites of immune privilege?
    The eyes, the brain, the placenta/uterus and the testis.
  6. These sites tend to be anatomically separated with little to no afferent or efferent lymph vessels-so few/no DC or T cells go in or out.
    Immunologically privileged sites.
  7. Has central tolerance ever been developed around immunologically privileged sites?
    No, because of isolation, tissue specific antigens have never been presented to lymphocytes during development in these areas.
  8. Because autoimmunity diseases are mediated by agents of adaptive immunity (B and T cells), by definition the responses must be directed against ____.
    Specific antigens
  9. What is the target of an autoreactive T cell or B cell-produced antibody called?
  10. Can one have autoreactive T and B cells in the absence of autoimmune disease?
  11. Autoimmune disease occurs when what three things happen?
    1. Tolerance is broken

    2. Effectors of immunity destroy healthy tissues faster than they can be repaired.

    3. The tissue is damaged to the point where organ dysfunction is clinically apparent.
  12. What type hypersensitivity is not reflected in autoimmunity?
    Type I (IgE)
  13. Goodpasture's syndrome is what type of autoimmunity?
    Type II
  14. This disease is characterized by glomerulonephritis and bleeding into the lungs.
    Goodpasture's Syndrome
  15. 1. For Goodpasture's syndrome, this autoantigen is found as a component of basement membranes in tissues throughout the body.
    1. Alpha-3 chain of type IV collagen
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Chapter 13 Immuno
2014-04-21 02:14:55
Chapter 13

Chapter 13 Immuno
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