PHRD5925 Pharmaceutics Lecture 17 - Tablets, Capsules

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daynuhmay
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PHRD5925 Pharmaceutics Lecture 17 - Tablets, Capsules
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2014-04-21 04:41:26
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tablets Capsules
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tablets, Capsules
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  1. 3 types of compressed tablets
    • 1) SCT (sugar coated)
    • 2) FCT (film coated)
    • 3) MCT (multiple compressed)
  2. mechanism of effervescent tablets
    liberate CO2 which acts as a disintegrator & produces effervescence
  3. inert substance added to increase the bulk weight of a tablet (filler)
    diluent
  4. types of diluents (4)
    • 1) clays
    • 2) salts
    • 3) sugars
    • 4) polysaccharides (starch)
  5. used to impart cohesive qualities to the powdered material to insure the tablet remains intact after compression, as well as improve the free-flowing qualities by the formulation of granules of desired hardness & size
    binders (glues)
  6. 3 commonly used binders
    • 1) sugars
    • 2) polysaccharides (*cellulose derivatives*), gums
    • 3) gelatin
  7. useful binder for drugs that are not stable in water (both water AND alcohol soluble)
    PVP (polyvinylpyrrolidone)
  8. API
    active pharmaceutical ingredient
  9. prevent adhesion of tablet material to surface of dyes, reduces inter-particle friction, improves flow rate
    lubricants
  10. 3 types of lubricants
    • 1) talc
    • 2) fatty acids, oils
    • 3) PEG
  11. how lubricants work
    make surfaces "non-sticky" by preventing polar interactions
  12. substances that promote the flow of the tablet granulation or powder by coating the tablet
    glidants
  13. 2 examples of glidants
    • 1) colloidal silicon dioxide
    • 2) talc
  14. how glidants work
    negatively charged glidant particles absorb on granule surface & prevent adhesive interactions between granules
  15. added to tablet to facilitate its breakup after administration
    disintegrant
  16. most important quality of a disintegrant
    ability to rapidly absorb water
  17. 4 examples of disintegrants
    • 1) corn/potato starch
    • 2) clays
    • 3) polysaccharides
    • 4) superdisintegrants (crosslinked polymers)
  18. when disintegrating agent is usually mixed
    w/ active ingredients & diluents prior to granulation
  19. used to keep tablets dry
    adsorbents
  20. 3 features of granulation
    • 1) ensures homogenous mixing of ingredients
    • 2) improves flow
    • 3) improves compressibility
  21. most widely used method of granulation
    wet granulation
  22. when dry granulation is used
    tablet ingredients are sensitive to moisture or are unable to withstand elevated temperatures during drying
  23. partial or complete separation of top or bottom crowns of a tablet from the main body (usually from air entrapment)
    capping
  24. separation of a tablet into 2+ distinct layers (usually results from air entrapment)
    lamination
  25. unequal color distribution on a tablet
    mottling
  26. 4 components of film coatings
    • 1) polymers
    • 2) plasticizers
    • 3) colorants
    • 4) solvents
  27. 3 things hard capsules contain
    • 1) gelatin
    • 2) colorant
    • 3) opacifier (sometimes)
  28. 3 things soft elastic capsules contain
    • 1) gelatin
    • 2) plasticizer (sorbitol, glycerol)
    • 3) preservative

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