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lcunrod7
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what are the two methods of transport of oxygen
dissolved O2 and bound to Hb
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what method is in plasma ~1.5%
dissolved O2
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what method is bound to iron in center of heme, 98.5% carried this way, "oxyhemoglobin"
boung to Hb
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what % of heme units that contain O2 at any given moment
hemoglobin saturation
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what is a very small change in the Po2 results in big change in the ability of Hb to bind O2 (or release O2)
steep slope
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what are the two factors which affect how much O2 binds to Hb
Ph and temperature
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when there is and increase curve "shifts" left Hb wants to release less O2
Ph
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when there is a decrease curve "shifts" right Hb wants to release more O2
pH
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20C decrease Hb release less O2
temperature
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40C increase Hb release more O2
temperature
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what by product of glycolysis (make ATP) reaction in RBC's,
BPG production
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increase BPG = increase release of O2 by Hb
BPG production
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what is a by product of aerobic metabolism in peripheral tissues
CO2
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what are the methods of CO2 transport
carbonic acid 70% , bound to globular protein subunits of Hb 23%, dissolved in plasma 7%
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what is in red blood cells, CO2—> carbonic anhydrase —> carbonic acid (H2CO3) —> H+(hydrogen ion) plus HCO3- (bicarbonate ion)
carbonic acid
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what has carbaminohemoglobin (HbCO2)
bound to globular protein subunits of Hb
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