HematologyTest2GranulocytesandMonocytes

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Author:
victimsofadown
ID:
271699
Filename:
HematologyTest2GranulocytesandMonocytes
Updated:
2014-04-23 23:32:09
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HematologyTest2GranulocytesandMonocytes
Folders:
HematologyTest2
Description:
HematologyTest2GranulocytesandMonocytes
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  1. What are the stages of myelopoiesis/granulocytopoiesis?
    • Myeloblast
    • Promyelocyte
    • Myelocyte
    • Metamyelocyte
    • Band
    • Segmented
  2. Describe neutrophil kinetics (timeframe + location + cell ratios) during development
    • Mitotic: 1 day¬†
    • in marrow
    • 1 myeloblast: 2 promyelocytes: 12 myelocytes

    • Post-Mitotic: 10 days
    • in marrow
    • 16 metamyelocytes: 12 bands: 7 segs

    Bands/segs spend 10 hours in blood then go to tissues/body cavities
  3. What morphological changes occur during granulocyte maturation/differentiation?
    • Reduction in nuclear volume
    • Condensation of chromatin
    • Change in nuclear shape
    • Appearance and subsequent decrease of primary granules
    • Appearance and subsequent increase of secondary granules
    • Color changes in cytoplasm (blue -> pink)
    • Changes in cell size (smaller)
  4. What functional properties change during neutrophil maturation/differentation?
    • Surface area is less negatively charged (less nuclear material)
    • Increased adhesiveness (for functionality)
    • Lower resistance to deformation (for functionality)
    • Increased spreading (for functionality)
    • Pseudopod activity increases (for functionality)
    • Increased speed of migration (for functionality)
    • Ability to phagocytose
  5. What are the stages of monocyte maturation of differentiation?
    • Monoblast
    • Promonocyte
    • Monocyte
  6. Describe monocyte kinetics (timeframe + location) during development
    • Bone marrow for 55 hours
    • Blood for 12 hours
    • May live for several months/years
  7. What morphological changes occur during granulocyte maturation/differentiation?
    • Condensation of nuclear chromatin
    • Change in nuclear shape
    • increase in cytoplasm
    • Appearance of cytopasmic granules
    • Color changes in cytoplasm
    • Appearance of vacuoles

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