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  1. Give general information about Myelodysplastic Syndromes? (characterized by? age affected? presentation?)
    • Diverse group of closely related disorders
    • Characterized by ineffective hematopoiesis, neoplastic clonal stem cell proliferations
    • Affect persons 60+
    • Presentation often similar to leukemia
    • Varies in presentation and course
  2. What are myeloproliferative disorders? What specific disorders are included?
    • Acquired malignant clonal proliferations of stem cells
    • idiopathic myelofibrosis
    • Polycythemia vera
    • Essential primary thrombocythemia
  3. Give general information about Plasma Cell disorders. (characterized by? Age? Etiology?)
    • Plasma cells are normally 1.5% of nucleated marrow cells
    • Proliferation of plasma cells and/or plasmacytoid lymphocytes (associated with monoclonal production of Ig)
    • Polyclonal increases are reactive
    • Occurs after the age of 40
    • Etiology unknown
    • Types include¬†Multiple myeloma and Waldenstroms macroglobulinemia
  4. Information about Lymphomas (definition? Etiology?)
    • Solid tumor with a proliferation of one of more types of cells from the lymphoid series
    • Initially develops in areas such as marrow, spleen, or lymph nodes
    • Can disseminate into blood
    • Unknown etiology (same things that cause leukemias)
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