Therapeutics: Viral Hepatitis 3

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Author:
kyleannkelsey
ID:
272057
Filename:
Therapeutics: Viral Hepatitis 3
Updated:
2014-04-26 23:23:08
Tags:
Therapeutics Viral Hepatitis
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Therapeutics: Viral Hepatitis 3
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Therapeutics: Viral Hepatitis 3
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  1. What are the treatment options for HCV genotype 3, treatment naïve patients?
    • Sofosbuvir + Ribavirin for 24 weeks
    • OR
    • Sofosbuvir, Ribavirin, and Interferon for 12 weeks
  2. What is not recommended for treatment in HCV genotype 3, treatment naïve patients?
    • Monotherapy with any drug
    • Interferon + Ribavirin for 24-48 weeks
    • Telaprevir, Boceprevir, or Simeprevir based regimens
  3. What is not recommended for treatment in HCV genotype 4, treatment naïve patients?
    • Sofosbuvir, Ribavirin, and Interferon for 12 weeks
    • Simeprevir x 12 weeks + Ribavirin, and Interferon for 24-48 weeks
    • Sofosbuvir and Ribavirin for 24 weeks if Interferon ineligible
  4. What is not recommened for treatment in HCV genotype 4, treatment naïve patients?
    • Monotherapy with any drug
    • Interferon + Ribavirin for 48 weeks
    • Telaprevir or Boceprevir based regimens
  5. What is not recommended for treatment in HCV genotype 5/6, treatment naïve patients?
    • Sofosbuvir, Ribavirin, and Interferon for 12 weeks
    • Ribavirin plus Interferon for 48 weeks
  6. What is not recommended for treatment in HCV genotype 5/6, treatment naïve patients?
    • Monotherapy with any drug
    • Telaprevir or Boceprevir based regimens
  7. Simeprevir is use in what genotypes of HCV?
    1 and 4
  8. Ribavirin is use in what genotypes of HCV?
    All
  9. Peg interferons are used in what genotypes of HCV?
    All but 2 (1,3,4,5,6)
  10. Sofosbavir is used in what genotypes of HCV?
    All
  11. How should you treat a HCV/HIV Co-infection?
    Sofosbuvir based regimen due to low potential for DDI with HIV medications
  12. How should you treat a Recurrent HCV Post-Liver Transplant?
    Sofosbuvir based regimen w/wo Ribavirin (start Ribavirin at lower dose & titrate up)
  13. How should you treat Decompensated Cirrhosis HCV?
    Sofosbuvir + Ribavirin x 48 weeks
  14. How should you treat Renal Impairment or Dialysis HCV patients?
    • Dose adjust Interferons once CrCL<30 or if on Dialysis
    • Dose adjust for Ribavirin when CrCL<50
    • (Sofosbuvir & Simeprevir not studied w CrCL<30)
  15. What is a Rapid Virological Response (RVR)?
    Uundetectable viral load at week 4 of treatment
  16. What is a Early Virological Response (EVR) ?
    At least 2 log reduction in viral load or undetectable viral load by week 12 of treatment
  17. What is a Sustained Virological Response (SVR)?
    undetectable viral load at conclusion of therapy and 24 weeks later
  18. What is a Null responder ?
    Viral load that never decreased by > 2 logs after treatment
  19. What is a Nonresponder?
    Detectable viral load after 24 weeks of therapy
  20. Lamivudine can be used for what hepatitis type?
    HBV
  21. Adefovir can be used for what hepatitis type?
    HBV
  22. Entecavir can be used for what hepatitis type?
    HBV
  23. Tenofovir can be used for what hepatitis type?
    HBV
  24. Telbivudine can be used for what hepatitis type?
    HBV
  25. Alfa-2a (Pegasys) can be used for what hepatitis type?
    Both HBV and HCV
  26. Alfa-2b (PegIntron) can be used for what hepatitis type?
    HCV
  27. Ribavirin can be used for what hepatitis type?
    HCV
  28. Sofosbuvir can be used for what hepatitis type?
    HCV
  29. Simeprevir can be used for what hepatitis type?
    HCV
  30. Telaprevir can be used for what hepatitis type?
    HCV
  31. Boceprevir can be used for what hepatitis type?
    HCV

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