Therapeutics: IBD 1

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Therapeutics: IBD 1
2014-04-27 14:48:25
Therapeutics IBD

Therapeutics: IBD 1
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  1. What is the brand name for Tegaserod?
  2. What is the generic name for Zelnorm?
  3. What is the MOA of Tegaserod (Zelnorm)?
    • 5-HT4 receptor partial agonist
    • Increases GI secretions & motility
    • Decreases visceral sensations
  4. What is Tegaserod (Zelnorm) used for?
  5. What is unique about Tegaserod (Zelnorm)?
    • Available through restricted access at Novartis
    • Only approved for women
    • (only studied in women)
  6. What is the dose for Tegaserod (Zelnorm)?
    2mg or 6mg BID prior to meal
  7. What drugs are available for IBS-C and Chronic idiopathic constipation (CIC)?
    • Linaclotide (Linzess)
    • Lubiprostone (Amitiza)
  8. What is the dose for Linaclotide (Linzess)?
    • 290mcg PO QD for IBS-C
    • 145 mcg PO QD for CIC
    • Take on empty stomach
  9. What group should not receive Linaclotide (Linzess)?
    NOT for use Age<18
  10. What is the brand name for Linaclotide?
  11. What is the generic name for Linzess?
  12. What is the dose for Lubiprostone (Amitiza)?
    • 8mcg PO BID for IBS-C
    • 24mcg PO BID for CIC
  13. What is the brand name for Lubiprostone?
  14. What is the generic name for Amitiza?
  15. What drugs are available for IBS-D?
    • Loperamides
    • Dicyclomine
    • Rifaximin
    • Alosetron
  16. What is the first treatment option for IBS-D?
    Avoid or restrict caffeine, alcohol, lactose, artificial sweeteners
  17. What is the IBS-D dose for Loperamide?
    Start at 2-4mg PO QID
  18. What is the IBS-D dose for Dicyclomine?
    Start at 20mg PO QID
  19. What is the IBS-D dose for Rifaximin?
    550mg PO TID
  20. What is Donnatal?
    • Anticholinergic/Antimuscarinic agent
    • Cobmination of: Hyoscyamine, Scopalamine, Atropine
    • Meant to combat spasming
  21. What is unique about Alosetron (Lotronex)?
    • Available through restricted access program
    • Only approved for women
  22. What is the MOA of Alosetron (Lotronex)?
    • 5-HT3 ANTagonist
    • Increases intestinal transit time
    • Decreases visceral sensations
    • Increases water/sodium absorption
  23. What is the dose for Alosetron (Lotronex)?
    0.5-1 mg BID
  24. Drugs for IBS mainly target what?
  25. What is the brand name for Alosetron?
  26. Drugs for IBD mainly target what?
    Inflammation and immune response
  27. What presentation only indicates Crohn’s diseae and not UC?
    • Perianal Fistula/Fissure
    • Malnutrition
  28. What presentation only indicates Ulcerative Colitis and not Crohn’s disease?
    • Hemorrhoids, anal fissures and perirectal abscess
    • Ocular involvement
    • Dermatologic disorders
    • Decreased HGB and HCT
  29. What presentation could indicate wither UC or Crohn’s
    • Abdominal pain/cramping
    • Frequent bowel movements
    • Weight loss
    • Arthritis
    • Malaise & Fever
    • Increased WBC, ESR, CRP
  30. What is at the bottom of the treatment pyramid for IBD (least aggressive)?
    Amino salicylates
  31. How do Sulfasalazine and Mesalamine compare?
    Mesalamine is the activated form of prodrug Sulfasalazine
  32. What is the most commonly used Amino salicylate for IBD?
  33. What are the formulations for Mesalamine?
    • Rowasa
    • Canasa
    • Delzicol
    • Pentasa
    • Lialda
    • Apriso