Conventional Anti Psychotic Drugs
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Give an example of a conventional anti psychotic drug and describe its function
- Blocks D2 receptors by binding to them and occupying their binding site
- This prevents the dopamine from binding and means fewer impulses are sent
What are conventional drugs useful for?
- Treating type 1 symptoms
- The treatment of acute type one symptoms of schizophrenia with conventional neuroleptics has proven to be highly effective
What did Cole et al find in 1964?
- P's took chlorpromazine for 6 weeks whilst a control group took sugar pills
- 0% got worse (48% in the control group)
- 5% showed no change (13% in CG)
- 18% showed some improvement (14% in CG)
- 75% showed much improvement (25% in CG)
What did Loebel find in 1992?
- Not all patients respond to conventional drugs
- 16% failed to show any improvement within 12 months of the first treatment
How do conventional drugs lack in effectiveness?
They are not effective in treating type two symptoms such as catatonic behaviour
Name and describe 2 side effects of conventional drugs
- Parkinsonism: Tremours or shuffling gait (due to lack of dopamine)
- Tardive Dyskinasea: Involuntary movements of the head and tongue
What did Hill find in 1986?
- 30% of people taking anti psychotic drugs developed Tardive Dyskinasea
- In 75% of cases, the condition is irreversible
What are the implications of severe side effects for patients?
- Loss of lifestyle
- Social stigma (pulling weird faces in public)
- Failure to socialise or hold down a job
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