Therapeutics: CKD 1

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Author:
kyleannkelsey
ID:
272399
Filename:
Therapeutics: CKD 1
Updated:
2014-04-29 11:13:21
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Therapeutics CKD
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Therapeutics: CKD
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  1. What does KDOQI stand for?
    Kidney Disease Outcomes Quality Initiative
  2. What does KDIGO stand for?
    Kidney Disease Improving Global Outcomes
  3. What is a decreased GFR?
    <60 ml/min/1.73m2
  4. What puts a person at “Increased risk” but not a specific stage of CKD?
    ≥ 60 (normal), with CKD risk factors, but without markers of damage
  5. Describe KDOQI Stage 1 of kidney failure:
    • Kidney damage with normal or á GFR
    • GFR: ≥ 90
  6. Describe KDOQI Stage 2 of kidney failure:
    • Kidney damage with mild decreased GFR
    • GFR: 60-89
  7. Describe KDOQI Stage 3 of kidney failure:
    • Moderate decreased GFR
    • GFR: 30-59
  8. Describe KDOQI Stage 4 of kidney failure:
    • Severe decreased GFR
    • GFR: 15-29
  9. Describe KDOQI Stage 5 of kidney failure:
    • Kidney failure, ESRD
    • GFR: <15 or dialysis
  10. What are the stages for KDIGO?
    G1, G2, G3a, G3b, G4, G5
  11. What is a KDIGO G1:
    • Normal or increased GFR
    • GFR: ≥ 90
  12. What is a KDIGO G2:
    Mildly decreased GFR GFR: 60-89
  13. What is a KDIGO G3a:
    • Mildly to moderate decreased GFR
    • GFR: 45-59
  14. What is a KDIGO G3b:
    • Moderate to severely decreased GFR
    • GFR: 30-44
  15. What is a KDIGO G4:
    • Severely decreased GFR
    • GFR: 15-29
  16. What is a KDIGO G5:
    • Kidney failure
    • GFR: <15
  17. What are the 4 main disease associated with CKD?
    • Diabetes mellitus
    • Hypertension
    • Glomerulonephritis
    • Polycystic kidney disease
    • (top two the most)
  18. What is KDOQIs cutoff for proneinuria?
    >200 mg/g
  19. What is KDOQIs cutoff for microalbuminuria?
    • >30 mg/g
    • (also says: Women = 25-355 and men 17-250)
  20. What concentration of protein in the urine constitutes a Negative test result for a spot urine dipstick?
    10 mg/dL
  21. What concentration of protein in the urine constitutes a Trace test result for a spot urine dipstick?
    10-20 mg/dL
  22. What concentration of protein in the urine constitutes a 1+ test result for a spot urine dipstick?
    30 mg/dL
  23. What concentration of protein in the urine constitutes a 2+ test result for a spot urine dipstick?
    100 mg/dL
  24. What concentration of protein in the urine constitutes a 3+ test result for a spot urine dipstick?
    300 mg/dL
  25. What concentration of protein in the urine constitutes a 4+ test result for a spot urine dipstick?
    >1000 mg/dL
  26. What is ADAs cutoff for proneinuria (macroalbuminuria)?
    >300 mg/g
  27. What is ADAs cutoff for microalbuminuria?
    >30 mg/g
  28. According to KDOQI , a Diabetic, Normotensive, Normoalbuminuric patient should receive what level of primary preventative care to avoid neuropathy?
    • NO ACEI or ARB
    • Primary Prevention stratagies
  29. According to KDOQI , a Diabetic, Normotensive, Micro/Macro-albuminuric patient should receive what level of primary preventative care to avoid neuropathy?
    ACEI or ARB
  30. According to KDOQI , a Diabetic, Hypertensive, Micro/Macro-albuminuric patient should receive what level of primary preventative care to avoid neuropathy?
    ACEI or ARB
  31. What are the primary prevention strategies for proneinuria?
    • Protein restriction = 0.6 g/kg/day
    • Smoking cessation
    • Weight loss
    • HTN control
    • Glycemic control
    • Anemia treatment
  32. What is the JNC 8 goal BP for CKD?
    Less than 140/90
  33. When should you add an ACEI or ARB in CKD according to JNC-8 and then what is the goal?
    • HTN is greater than or equal to 140/90
    • Titrate to goal of < 140/90
  34. What is the MOA of ACEIs and ARBs in preventing Diabetic neuropathy?
    • Decrease efferent arteriolar tone
    • Reduce pressure in the glomerulus
    • Renoprotective
    • + decreases proteinuria
    • Reduce doubling SCr
    • Reduceprogression to ESRD

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