Micro exam 3 virus

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leamusic
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272510
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Micro exam 3 virus
Updated:
2014-05-16 10:51:04
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Micro exam virus
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Micro exam 3 virus
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Micro exam 3 virus
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  1. Orthomyxovirus
    • *DNA virus*
    • Influenza A: agent of flu
    • HA & NA 
    • drift & shift
    • 8 segments
  2. Parovirus - B19
    • *DNA virus*
    • Fifth Disease
    • slapped cheek rash 
    • no envelope
  3. poxvirus
    • *DNA virus* 
    • Smallpox, Molluscum contagiosum (MCV)
    • replication in cytoplasma (so big!) 
    • MCV: small skin tags - will go away
    • Only 1 antigen = vaccine very effective 
  4. Herpesviruses
    • *DNA virus*
    • HHV-1 through HHV-8
    • Enveloped derived from nuclear membrane
    • Most are latent infections
    • 1: Herpes simplex 1 (oral) 
    • 2: Herpes simplex 2 (genitals)
    • 3: Varciella - VZV (chicken pox/shingles)
    • 4: Epstein Barr - EBV (mono) 
    • 5: Cytomegalovirus - CMV (neonates) 
    • 6: HHV-6 - Roseola - sixth disease  
    • 7: similar to sixth disease
    • 8: HHV-8 - Kaposi's sarcoma-related virus (AIDS)
  5. HHV-1
    • oral herpes
    • Latency-associated Transcripts (LATs) promotes long survival
  6. HHV-2
    • Genital herpes, STD
    • no effective treatment
    • sores will come & go
  7. HHV-3
    • Varicella Zoster Virus (VZV)
    • Chicken pox & Shingles 
    • Live vaccine available for both!
  8. HHV-4
    • Epstein Barr Virus (EBV) 
    • MONO!!!! 
    • Supportive therapy & sleep
    • Targets B lymphocytes (latent in B cells) - T cells attack! 
  9. HHV-5
    • Cytomegalovirus (CMV)
    • SIGNIFICANT IN NEONATES
    • viremia - virus in blood
  10. HHV-6
    • Roseola - sixth disease 
    • Latency in T cells
  11. HHV-7
    **similar to sixth disease
  12. HHV-8
    • Kaposi's sarcoma-related virus 
    • latency in B cells
    • rarely leads to anything 
    • AIDS pts be careful
  13. Hepadnavirus
    • *DNA virus*
    • Heptatitis B, STD 
    • ENVELOPED
    • Partially dsDNA
    • Reverse Transcriptase 
    • BAD when connected with HepD
  14. Adenovirus
    • *DNA virus*
    • NOT a latency virus 
    • inflamed adenoids
  15. Papillomavirus
    • Warts 
    • no envelope 
    • uses host cell DNA polymerase
  16. HPV
    • cervical warts
    • bad ones = type 16 & 18 
    • Vaccine available - Gardasil
  17. Polyoma
    • *DNA virus*
    • BK virus: renal disease
    • JC virus: neuropathy 
    • Merkel Cell Virus: type of skin cancer
    • NO ENVELOPE
  18. (PICO) Enterovirus
    • *ssRNA*
    • Polio virus 
    • VAPP
    • Coxsackie
    • ECHO Virus 
    • spread by fecal-oral route
  19. Poliovirus
    • *(PICO) Enterovirus*
    • Polio: neural tissue damage
    • viral spread
    • get from water supply
    • Salk vaccine - inactive form - used today
    • Sabin vaccin - oral form - could cause polio symptoms! (VAPP)
  20. Coxsackie
    • *(PICO) Enterovirus*
    • A & B causes paralytic disease
  21. ECHO virus
    • *(PICO) Enterovirus*
    • enteric cytopathic human orphan
    • rarely a disease
  22. (PICO) Rhinovirus
    • *ssRNA* 
    • common cold
  23. (PICO) Heparnavirus
    • *ssRNA* 
    • HepA (HAV) 
    • usually self-limited 
    • acquired from shellfish 
    • keep good hygiene!
  24. Calicivirus
    • *ssRNA* 
    • Norovirus - cruise ships… 
    • HepE - BAD in PG women
    • NO envelope 
    • ODD: environmentally tough AND very infectious… 
  25. Togavirus...
    • *ssRNA* 
    • RUBELLA!!! German Measles
    • MMR vaccine shot 
    • Enveloped, Mosquitoe vector 
    • Congenital defects could result!!
  26. Flavivirus
    • *ssRNA* 
    • West Nile: no vaccine, spread by mosquitoes
    • Yellow Fever: vaccine, spread by mosquitoes
    • HepC: WORST hepatitis, liver damage, 80% are asymptomatic!!
    • ENVELOPED
  27. Coronovirus
    • Common cold 
    • SARS (severe acute respiratory syndrome) will kill you 
    • enveloped
  28. Paramyxovirus
    • Measles, mumps
    • CHILDHOOD DISEASES!!! 
    • MMR vaccine
  29. Measles
    • *from paramyxovirus* 
    • Childhood illness
    • only 1 serotype - effective MMR vaccine
    • Measles rash 
    • Koplik's spots in mouth = DIAGNOSTIC!!
  30. Mumps
    • *from paramyxovirus* 
    • Childhood illness
    • Parotitis is obvious symptom!! - swollen neck
    • Worse than measles?
    • use MMR vaccine
  31. Respiratory Syncetial Virus (RSV)
    • cell globs = "syncytia"
    • Palvizumab - monoclonal antibodies
    • Childhood disease - pretty mild 
    • Broncholitis/pneumonia
    • WASH HANDS
    • no vaccine available 
  32. Parainfluenza
    • CROUP - caused by type 1 
    • F (fusion) protein is a major factor!!
  33. Bunyavirus
    • Hanta virus 
    • very rare
  34. Rhabdovirus
    • RABIES (from bats, raccoons)
    • Phases of infection: Incubation, Prodome, Neurologic, Coma, Death 
    • animal bites (don't let it hit the CNS)
    • VERY SLOW PROGRESSION
    • Get vaccine after you get bite
  35. Reovirus
    • Rotavirus: causes GI & diarrhea 
    • no envelope
  36. Oncovirus
    • *Retrovirus* 
    • a piece of DNA - may recombine to become cancer!!!
    • Human T-lymphotrophic Virus (HTLV-1 & 2) 
  37. HTLV-1
    • *Retrovirus* 
    • oncovirus…
    • infects: Helper T cells & DTH cells
    • Causes adult acute T-cell lymphocytic leukemia 
  38. HTLV-2
    • *Retrovirus* 
    • oncovirus… 
    • atypical forms of hairy cell leukemia
  39. HIV
    • *Retrovirus* 
    • severe immune deficiency disease 
    • SO BAD!!! - infects dendritic cells 
    • latent ONLY when dsDNA
    • fall below 200/uL 
    • pt may appear healthy for years
    • use cocktail drug (2 NATIs + 1/2 NNRTIs) (or a protease inhibitor)

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