Card Set Information
what disease has these characteristics:progressive memory loss,impaired thinking, neuropsychiatric symptoms, inability to perform routine tasks of daily living
Pathophysiology of Alzheimer's
the degeneration of neurons early in hippocampus and then later in the cerebral cortex. Also reduced cholinergic transmission.
Risk factors for Alzheimer's
low educational level
high levels of homocysteine
nicotine in cigarette smoke
Symptoms of Alzheimer's (beginning)
difficulty with self care
wandering, pacing, agitation, screaming, inability to recognize family members
inability to communicate
Later symptoms of Alzheimer's
loss of speech
loss of appetite
loss of bladder and bowel control
total dependence on caregiver
when do symptoms begin to show for Alzheimer's
life expectancy from symptom onset
How to diagnose Alzheimer's
age and clinical evaluation
can only definitively diagnose through autopsy
Treatment for Alzheimer's
drug therapy for Alzheimer's
goal is to treat the symptoms
none of them are very effective
How much time can you buy by using drugs for Alzheimer's?
Types of drugs used in Alzheimer's
neuronal receptor blocker and cholinesterase inhibitors
Effect of cholinesterase inhibitors of Alzheimer's
delays the progression of disease by preventing the breakdown of ACh
Negative side effect of Tacrine
Adverse effects of Cholinesterase inhibitors
How do you start cholinesterase inhibitors on a patient?
start on a low dose so that they get used to the side effects and then gradually increase dose
what type of drug is memantine?
a NMDA receptor antagonist
Adverse effects of NMDA
How can NSAIDs help prevent Alzheimer's?
NSAIDs prevents inflamation and since Alzheimer's is an inflammatory process, it can help prevent the disease