Workman 16-17 review.txt
Card Set Information
Workman 16-17 review.txt
drugs high lipids affecting blood clotting
Workman chapters 16-17
Normal Values: total cholesterol
< 200 mg/dL
: > 239
Normal Values: Low-density lipoprotein (LDL)
: < 35
Normal Values: Very low-density lipoprotein (VLDL)
Normal Values: High-density lipoprotein (HDL)
: > 45 mg/dL
: > 55 mg/dL
Normal Values: Triglycerides
: 40-160 mg/dL
: 35-135 mg/dL
What are adverse effects of atorvastatin (Lipitor)?
May develop rhabdomyolysis (muscle breakdown).
: general muscle soreness, muscle pain and weakness, vomiting, stomach pain, and brown urine (contains pieces of broken-down muscle)
Before giving statins:
Baseline kidney function tests (blood urea nitrogen [BUN} and creatinine); kidney failure a side effect of rhabdomyolysis.
Should pregnant or breastfeeding women take statin drubs?
cholestyramine (Questran) is what kind of drug?
Bile acid sequestrant
How should bile acid sequestrants be taken with antacids?
2 hours before or 2 hours after antacids.
What do Fibrates do?
Decrease blood triglyceride levels and cause mild increase in HDL.
Decrease liver production of triglycerides and increase use of triglycerides by fat tissues for metabolism.
Name a common fibrate:
What should patients avoid consuming while taking fibrates?
What are the intended responses of niacin (Niaspan)?
: total cholesterol level
: total triglyceride level
What are adverse effects of niacin?
stomach ulcer flare-up (reduce GI effects
: take with meals)
The normal range for activated partial thromboplastin time (aPTT) is:
Mean normal range in seconds established by laboratory.
The therapeutic range for activated partial thromboplastin time (aPTT) is:
1.5-2.5 times mean normal range in seconds established by laboratory.
The normal range for international normalized ratio (INR) is:
The therapeutic range for international normalized ratio (INR) is:
How to give heparin:
Do not aspirate before injection.
Do not expel air bubble before injection.
Deep subcut with client lying down.
Name a thrombin inhibitor:
What is the antidote for heparin
IV protamine sulfate
Name a clotting factor synthesis inhibitor:
What is the antidote for warfarin?
IM or IV vitamin K.
Should warfarin be given during pregnancy?
NO, warfarin is pregnancy category X and causes birth defects and bleeding in unborn child.
What drugs INCREASE the action of warfarin?
What drugs DECREASE the action of warfarin?
Drugs ending in plase are what class?
Common thrombolytic drugs