Individual Variation in Drug Responses
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three categories of drug tolerance
- pharmacodynamic tolerance
- metabolic tolerance
Which age group is sensitive to drugs
elderly and infants
what is tolerance?
decreased responsiveness to a drug as a result of repeated drug administration
what is pharmacodynamic tolerance
associated with long term administration of drugs such as morphine of heroin
what is metabolic tolerance
resulting from accelerated drug metabolism
what is tachyphylaxis
reduction in drug responsiveness brought on by repeated dosing over a short time
what is bioavailability?
ability of the drug to reach the systemic circulation from its site of administration
causes of variable absorption
changes in gastric pH, diarrhea, constipation, bioavailability, food in the stomach
Ways the genets can influence drug responses
it can alter drug metabolism, it can alter drug targets, gender, race,
How would diet cause variability of drug effects
low protein diets causes low protein binding of drugs and causes increased free drug
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