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mainstays of therapy for Bipolar disorder
lithium, valproic acid
what is bipolar disorder?
cyclic disorder where there are episodes of mania and depression that persist for months without treatment
How many cycles a year for Rapid cycling BPD?
4 cycles or more a year
types of episodes seen in BPD
pure manic episode
three categories of BPD
characteristics of bipolar 1
manic or mixed episodes that are usually depressive
Bipolar 2 characteristics
hypomanic or depressive episodes (no mixing)
does non drug therapy work for BPD?
types of drugs used for BPD
types of mood stabilizing drugs
anti epileptic drugs
mechanism of action of lithium
altered distribution of certain ions
altered synthesis and release of norepinephrine,serotonin and dopamine
mediates intracellular responses to neurotransmitters
shown to facilitate regeneration of damaged optic nerds
can increase total gray matter in regions known to atrophy in BPD
adverse lithium effects
What is drug interaction of NSAIDs wit lithium?
can change the release of Li
Types of anti epileptic drugs
What is lamotrigine used for in BPD?
indicated for long term maintenance
can be used alone or in combination
what are anti epileptic drugs used for in BPD?
control symptoms during manic episodes
used long term to stabilize mood
what is the hypomania phase
like they are on a high