how does the cleavage plane during cell division determine the cell's fate?
Thus, cell fate is regulated y differences in gene expression during development. Gene expression is regulated by cellular proteins called transcription factors. If transcription factors, or the upstream molecules that regulate them, are unevenly distributed within a cell, then the cleavage plane can determine which factors are passed on to the daughter cells. For example, proteins called notch-1 and numb migrate to different poles of ventricular zne precursor cells.
When the neuron divides vertically, the notch-1 and numb proteins are partitioned symmetrically. However, when the cell divides horizontally, notch-1 goes with the daughter that will migrate away, while numb remains with the cell that will divide again.
Research suggests that notch-1, unopposed by numb, activates the gene expression that causes the cell to cease dividing and migrate away from the ventricular zone