thera final schizophrenia

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coal
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272885
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thera final schizophrenia
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2014-05-02 16:56:44
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thera final schizophrenia
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  1. diagnostic criteria for schizophrenia
    • 1) delusions
    • 2) hallucinations
    • 3) disorganized speech
    • 4) grossly disorganized or catatonic behavior
    • 5) negative symptoms (affective flattening, alogia, anhedonia, avolition)

    2 or more symptoms, with 1 being a top 3, present for a significant portion of the time during a 1 month period
  2. epidemiology of schixophrenia
    excess dopamine
  3. risk factors of schizophrenia
    • family history
    • obstetric complications
    • developmental difficulties
    • CNS infections in childhood
    • cannabis use
    • acute life events
  4. positive symptoms of schizophrenia
    • hallucinations
    • delusions
    • disorganized speech/behavior
  5. negative symptoms of schizophrenia
    • affective flattening - lack of emotion
    • alogia - inability to speak
    • anhedonia - not getting pleasure from things you used to
    • avolition - lack of drive/motivation
  6. presentation of prodromal phase
    • multiple somatic complaints
    • decreased functional capacity
    • interest in religion
    • positive symptoms then they want to talk about them
  7. haloperidol MOA
    blocks D1 & D2 receptors
  8. adverse effects of haloperidol
    • QTc prolongatoin
    • EPS
    • sedation
    • wt gain
  9. AP depot preps
    • haloperidol - haldol
    • risperidone - Risperdal consta
    • paliperidone - invega
    • ariprazole - abilify maintena
    • ziprsidone - geodon
  10. early onset EPS
    w/I 4 weeks of treatment
  11. late onset EPS
    6-12 months after initiating drug therapy
  12. clozapine max dose
    900 mg/d
  13. indications for clozapine
    • high risk suicide
    • violent behavior
    • refractory schizophrenia

    if on this they have usually failed other Tx
  14. clozapine AE
    • agranulocytosis
    • hyperglycemia
    • wt gain
  15. risperidone AE
    hyperprolactinemia - causes lactation and gynecomastia
  16. AP most likely to cause insomnia
    risperidone - risperdal
  17. AP most likely to cause sialorrhea
    clozapine - clozaril
  18. olanzapine AE
    • hyperglycemia - metabolic syndrome
    • increased TG
    • wt gain
  19. which AP showed cognitive improvement
    olanzapine - zyprexa
  20. quetiapine AE
    • wt gain
    • sedation
  21. AP most likely to cause anticholinergic side effects
    quetiapine - seroquel
  22. which AP comes in a short acting IM form
    ziprasidone - geodon
  23. which AP showed an improvement in wt, A1C, TC and TG
    ziprasidone - geodon
  24. ziprasidone AE
    QTc prolongation
  25. which AP does not raise prolactin levels
    aripiprazole - abilify
  26. which AP would we probable avoid in cardiac pts due to the AE
    iloperidone - fanapt
  27. which AP is sublingual
    asenapine - saphris
  28. which AP has no QTc prolongation
    lurasidon - latuda

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