Therapeutics: GN

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  1. What is NephrOtic syndrome?
    Gaps in epithelial podocytes allow proteins to leak out
  2. What is Nephritic syndrome?
    Proliferation of mesangial cells or secondary inflammatory cells allows blood to spill out
  3. What are the laboratory changes for someone with NephrOtic syndrome?
    • Proteinuria > 3.5 g/day/1.73
    • Hyperlipidemia
    • Lipiduria
    • Hypercoagulation
  4. What are the laboratory changes for someone with NephrItic syndrome?
    • Proteinuria up to 3 g/day/1.73
    • Pus, cellular and granular debris
    • Hypoproteinemia
  5. What are the signs of Nephritic syndrome?
    • Hematuria
    • HTN and edema
  6. What are the signs of NephrOtic syndrome?
    • Edema
    • Weight gain
    • Fatigue
  7. What are the PE s/s of GN?
    • HTN
    • Rash
    • Arthritis
    • Retinopathy
    • Neuropathy
    • Lympadenopathy
    • Hepatosplenomegaly
    • Malignancy
  8. What is the first line treatment or GN?
  9. What are the immunosuppressive agents for GN?
    • Cotricosteroids
    • Cyclophosphamide
    • Chlorambucil
    • Azathiopurine
    • Cyclosporine, mycophenolate mofetil
  10. What is the last resort treatment for GN?
  11. What are the supportive therapies for GN targeted at?
    • Edema
    • HTN
    • Proteinuria
    • HLD
    • Hypercoagulable states
  12. How would you treat edema in GN?
    Salt restriction, loop diuretic or albumin (only if morbid edema)
  13. How ould you treat HTN in GN?
    ACEI or ARB + CCB (either type of CCB)
  14. How would you treat proteinuria in GN?
    • Dietary restriction to 0.6-0.8 g/kg/day
    • ARB or ACEI
  15. How do you treat HLD in GN?
    • Low fat diet and exercise
    • Statin
  16. When should you anticoagulate a GN patient?
    • Documented TE episode
    • OR
    • High risk: serum albumin <2-2.5 g/dL, prolonged bedrest, high dose IV steroids, dehydrated, post-surgery
  17. Glomerulopnephritis patients usually fall into what category of AKI?
  18. What is the treatment for Minimal change nephropathy?
    • Na/protein restriction
    • Responds well to prednisone 60 mg/m2/day x4-6 weeks
  19. What is Minimal change nephropathy?
    Spreading foot process of epithelial cells over GBM
  20. A thorough __________ can help identify factors that may contribute to the development of GN.
    Medical history
  21. Which type of GN will can you consider anticoagulants in?
    Membranoproliferative GN
  22. ___________ and ____________labs should be drawn to determine extent of renal dysfunction and proteinuria.
    Serum and urine
  23. Treatment for GN is usually ____________ and can include corticosteroids and/or cytotoxic agents.
Card Set:
Therapeutics: GN
2014-05-03 15:17:35
Therapeutics GN
Therapeutics: GN
Therapeutics: GN
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