DNA history

Card Set Information

Author:
lacythecoolest
ID:
273114
Filename:
DNA history
Updated:
2014-05-04 11:44:42
Tags:
cell bio
Folders:
bio 214
Description:
history of DNA
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  1. Law of Inheritance
    • mendel 1866
    • combination of peas
  2. miescher
    • 1869
    • found DNA from white blood cells
  3. boveri/sutton
    • 1902
    • sea urchin eggs required 2 parental gametes
    • chromosomes carry genetic information
  4. Heritable change
    • Griffith 1928
    • Mice w/S. & R. pneumoniae
    • S strand changed R strand
  5. Beadle/Tatum
    • 1941-neurospora, bread mold
    • mutated cells to find what was required to grow
    • Arginine
    • 1 gene=1 enzyme
  6. Transforming Principle
    • Avery/MacLeod/McCarthy-1944
    • T2R cell DNA added with RNAase, DNAase & protease
    • DNAase didn't grow
  7. Hersey/Chase 1940?
    • DNA is the changing factor
    • E coli/T2
    • grew T2 in radioactive medium
    • only DNA was found in E coli
  8. Equal # of nucleotides
    • Chargaff 1950
    • used many species
    • A's=T's
    • G's=C's
  9. Franklin-1952
    xrays found DNA to be helical shape
  10. Base pairing rules
    • Watson/Crick 1953
    • figured out DNA structure
  11. Meselson & Stahl
    • semiconser v. dispersive v. conservative
    • bacteria w/ N14 & N 15
    • middle of density gradient
    • heated, DNA separates, one is heavier then other=semiconservative!

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