Initially, respiratory alkalosis develops secondary to direct stimulation of the respiratory centers (hyperventilation).
This may be the only consequence of mild salicylism.
The toxic effects of salicylates are complex.
Respiratory centers are directly stimulated.
Salicylates cause an inhibition of the citric acid cycle and an uncoupling of oxidative phosphorylation.
A severe metabolic acidosis (ketolactic) acidosis with compensatory respiratory alkalosis may develop with severe salicylate intoxication.
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