PHRD5915 Drug Design Lecture 8 - Drug-Receptor Binding I

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daynuhmay
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274081
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PHRD5915 Drug Design Lecture 8 - Drug-Receptor Binding I
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2014-05-11 22:36:32
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Drug Receptor Binding
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Drug-Receptor Binding
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  1. extracellular molecular targets
    membrane bound R's
  2. intracellular molecular targets (3)
    • enzymes
    • proteins
    • DNA sites
  3. forces involved in drug-target interactions (6)
    • covalent
    • ionic
    • ion-dipole/dipole-dipole
    • charge transfer (-stacking)
    • hydrophobic (Van der Waals)
  4. intermolecular bond
    occurs between 2 separate molecules
  5. intramolecular bond
    occurs within one molecule
  6. interaction that generally occurs between 2 aromatic rings where 1 ring is electron deficient relative to the other
    charge-transfer (-stacking)
  7. substituents that have chemical or physical similarities which produce broadly similar biological properties
    bioisosteres
  8. compounds displaying a 3D arrangement of atoms that are non superimposable mirror images
    enantiomers
  9. compounds displaying a 3D arrangement of atoms that are not mirror images
    diastereomers
  10. difference between an active and inactive enantiomer
    active interacts w/ its target at 3 distinct points
  11. most naturally occurring medicinal agents exist in their optically ______ (active/inactive) form
    active
  12. triprolidine:
    1) active stereoisomer
    2) off-target effect of inactive stereoisomer
    • 1) E-triprolidine
    • 2) inactive
  13. triprolidine:
    1) molecular target
    2) treatment
    • 1) H1 antagonist
    • 2) anti-histamine
  14. ibuprofen:
    1) active stereoisomer
    2) off target effect of inactive stereoisomer
    • 1) S-ibuprofen
    • 2) inactive
  15. ibuprofen:
    1) molecular target
    2) disease/symptom
    • 1) COX inhibitor
    • 2) anti-inflammatory (NSAID)
  16. quinine:
    1) active stereoisomer
    2) off target effect of inactive stereoisomer
    • 1) R-quinine
    • 2) antiarrhythmic to regulate heartbeat
  17. quinine:
    1) molecular target
    2) disease/symptom
    • 1) unknown
    • 2) anti-malaria
  18. albuterol:
    1) active stereoisomer
    2) off target effect of inactive stereoisomer
    • 1) R-albuterol
    • 2) antagonizes R form
  19. albuterol:
    1) molecular target
    2) disease/symptom
    • 1) 2-adrenergic R agonist
    • 2) asthma drug bronchodilator
  20. methylphenidate:
    1) active stereoisomer
    2) off target effect of inactive stereoisomer
    • 1) R-methylphenidate
    • 2) loss of activity, LT drug effect
  21. methylphenidate:
    1) molecular target
    2) disease/symptom
    • 1) N/E-DA reuptake inhibitor 
    • 2) ADHD
  22. 5-fluorouracil isosteric replacement
    H replaced w/ F
  23. 5-fluorouracil:
    1) molecular target
    2) disease/symptom
    • 1) thymidylate synthase
    • 2) anti-cancer
  24. dexanabinol:
    1) active stereoisomer
    2) off target effect of inactive stereoisomer
    • 1) S-dexanabinol
    • 2) similar effects to natural THC (psychoactive)
  25. dexanabinol:
    1) molecular target
    2) disease/symptom
    • 1) NMDA-R antagonist
    • 2) neuroprotective agent to treat traumatic brain injury/stroke
  26. epinephrine:
    1) active stereoisomer
    2) off target effect of inactive stereoisomer
    • 1) R-epinephrine
    • 2) n/a
  27. epinephrine:
    1) molecular target
    2) disease/symptom
    • 1) adrenergic R's
    • 2) glaucoma

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