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  1. Antibiotic which disrupts cell wall synthesis in H. Pylori. Most effective at neutral pH (can work well with antacids);
  2. Antibiotic which disrupts cell wall in H. pylori causing lysis; inhibits urease activity; prevents H. pylori from adhering to gastric surface ("soap for the stomach"; bacteria do not develop resistance to this drug.
    Bismuth (bismuth subsalicylate)
  3. Proton-Pump Inhibitor (PPI); causes irreversible inhibition of H+/K+ ATPase (proton pump); _|_ gastric acid secretion; Effects persist until new enzyme is synthesized;
    For treatement of duodenal and gastric ulcers, erosive esophagitis, GERD (short-term treatment); For long-term treatment of hypersecretory problems.
    omeprazole [Prilosec]
  4. Antibiotic for treatement of PUD caused by H. pylori. Category D; can cause discoloration in developing teeth.
  5. For treatment and maintenance therapy of duodenal ulcers; Creates a protective barrier against acid and pepsin; No significant side effects
    sucralfate [Carafate]
  6. Histamine2 Receptor Antagonist (H2RA)
    First choice for gastric and duodenal ulcers (4-12 wks of tx)
    Suppresses secretion of gastric acid by binding with H2 receptors in parietal cells
    Also relieves symptoms of GERD
    Oral, IM, IV admin; antacids can decrease absorption
    _|_ Hepatic drug metabolizing enzymes
    cimetidine [Tagamet]
  7. Used to prevent prophylactically ulcers in pts taking NSAIDs (e.g. for surgery, etc)
Card Set
Drugs to treat Peptic Ulcer Disease and GERD
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