Pharmacology for the Cardiology Boards

Card Set Information

Author:
kevrhayes
ID:
274372
Filename:
Pharmacology for the Cardiology Boards
Updated:
2014-05-13 23:00:08
Tags:
Mayo DVD
Folders:

Description:
These are for board review
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user kevrhayes on FreezingBlue Flashcards. What would you like to do?


  1. Which CYP3A system in inhibitted by grapefruit juice?

    What does this mean for cardiac drugs?
    Intestinal CYP3A

    drugs metabolized by the INTESTINAL (not hepatic CYP3A are inhibited): dihydropyridine CCBs, lovastatin, simvastatin, cyclosporine, tacrolimus, sildenafil
  2. Which beta blockers are lipophilic?

    Hydrophilic?
    Metoprolol, labetalol, propranolol

    Atenolol, sotalol
  3. How does the volume of distribution change for elderly?

    For women?
    Small volume of distribution due to less muscle mass and less water content (both)
  4. What interaction does potassium have with digoxin?
    Hypokalemia leads to digoxin toxicity
  5. What is the treatment for beta blocker overdose?

    CCB?

    Caffeine
    glucagon, beta agonists, pacing

    Calcium, inotropes, vasopressors

    Beta blockers
  6. What is the treatment for digoxin toxicity?
    Digibind
  7. How are anthracyclines and cardiomyopathy related?
    Cumulative dose (about 500 mg/m2)
  8. What does anthracycline cardiomyopathy show on biopsy?
    myocyte death
  9. Hos is biologic chemo agent different from anthracyclines?
    Typically reversible
  10. What pathology is known with Xeloda?
    Coronary vasospasm (5FU based chemo)
  11. What effect does St. John's Wort have on cardiac medications?
    Inducer of CYP3A4 and CYP2D9 --> reduced bioavailability of amiodarone, CCBs, beta blockers, statins, warfarin
  12. What herbals increase bleeding risk?
    Garlic, ginger, gingko, saw palmetto
  13. What effect does Hawthorn have?
    increases dig effect; increases vasodilator effect of CCBs and nitrates
  14. What is the effect of licorice?

    Yohimbine?
    Increases spironolactone effect

    hypertension
  15. Why are elderly at risk for adverse drug reactions?
    decreased muscle mass (decreased volume of distribution), decreased renal function, cognitive decline, comorbid diseases, polypharmacy
  16. What is the risk of drug-drug interaction with 8 meds or more?
    100%
  17. What percent of clopidogrel taken in is actually activated?

    Which Cytochrome enzyme accounts for activation?
    15%

    CYP2C9

What would you like to do?

Home > Flashcards > Print Preview