1. A 72 year old man presents with pedal oedema and a cough. On examinatino there is macroglossia and carpel tunnel syndrome.You hear lung crackles. You note proteinurea.What could this be?
2. a 76 year old man has his spleen removed.you note the cut surface has a purple red colour, with flecked firm brown nodules. On microscopy, there is ectasis of the sinusoids.what is the cause of this?
3. A 68 year old male presents with renal impairmen. Serum shows raised IgM, which is monoclonal.What is this likely to be?
4. A male child presents with recurrent infections between the ages of 4 months and 3 years of age.They have deficiency of B cells and plasma cells and immunoglobulins. Their tonsils are not palpable.What might you consider?
X linked agammaglobulinaemia of Bruton-
5. A 9 month old child is diagnosed with Kostmann's syndrome.What might you expect them to present with?
life-threatening infection- neutropenia
6. A 45 year old male presents with Addison's disease.what other autoimmune disease might you consider in them?
7. a neonate has a cleft lip. On x ray you note the thymus is completely absent.which syndrome might you consider?
8. A 58 year old woman presents with a stroke. On bloods, you note thrombocytopaenia. No splenomegaly. Petechiae.What is this?
Thrombotic thrombocytopaenic purpura.-
9. In neonates, when is there a natural trough in antibody levels and in which order do they appear?
3-6 months- IgM, IgG, IgA
10. What is the commonest form of immunodeficiency, and what 2 kinds of infections are more common?
IgA deficiency- Sinopulmonary infection, GI (giardia, salmonella etc)
11. Which congenital arches are not developed in digeorge and which 2 organs are absent?
3rd and 4th branchial arches- thymus, parathyroid
12. What 5 conditions may precipitate reactive systemic amyloidosis and what kind of protein is involved?