Schizophrenia Studies 1
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Schizophrenia Studies 1
What did Meltzer find?
66% of patients that did not respond to typical antipsychotics responded to a 12 month course of Clozapine
What did Leuch et all find?
Did a meta analysis of studies
Atypical drugs were only moderately better for type 2 symptoms
Reviewed four studies involving atypical drugs
In 2 the drugs were slightly more effective
In 1 they were the same
In 1 they were slightly worse
What did McGlashan and Fenton find?
The catatonic subtype is very rare and could be caused by the anti psychotics that are taken
It isn't a true subtype of schizophrenia and should be dropped as such
What did Lieberman find?
Some people stay in the active phase for many years
In these cases type one symptoms in early years are replaced by type 2 symptoms later in life
What did Kendler et al find?
First degree relatives of schizophrenics are 18x more likely to develop schizophrenia
The national average is 1% likelihood
What did Gottesman and Shields find?
The more genetically similar you are to a schizophrenic, the more likely you are to be schizophrenic yourself
Schizophrenic sibling and parent
What were the results of the 5 studies from 1969-1976?
Concordance rates for schizophrenia between:
What did Heston find?
Of 47 mothers with schizophrenia who's children were adopted within days of birth by typical mothers, the instance of schizophrenia was 16%
What did Kety find?
High rates of schizophrenia were found in people who's biological parents had it but who had been adopted by psychologically healthy parents
What did Tienary find?
155 adopted children with schizophrenic mothers were compared to a matched group with no family history of schizophrenia
10% in group 1 were schizophrenic
1% in group 2 were schizophrenic
What did Myakawa find?
Studied DNA of schizophrenics
Affected seemed to have an affected gene PPP3CC- associated with the production of an enzyme
GMO mice deprived of this gene displayed schizophrenic symptoms
What did Wong et al find?
PET scans were carried out on the brains of schizophrenics
A higher density of dopamine activity was recorded in schizophrenic brains than the control group
What did Durand and Barlow find?
Serotonin plays a bigger part in schizophrenia
Serotonin is a master neurotransmitter that controls other neurochemicals such as dopamine
New drugs such as clozapine that are more effective in reducing symptoms affect serotonin rather than dopamine
What did Bateson find?
Parents communicate contradictory messages to their children
They say one thing but their tone or gestures or tone communicate the opposite
One message is conveyed on the verbal level but another is conveyed on the non verbal level
What did Brown find?
Schizophrenia development is augmented when someone is in a negative emotional climate
What did Schiffman et al find?
Expressed emotion is a stress factor possibly causing or contributing to the development of schizophrenia