Schizophrenia Studies 1

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  1. What did Meltzer find?
    66% of patients that did not respond to typical antipsychotics responded to a 12 month course of Clozapine
  2. What did Leuch et all find?
    • Did a meta analysis of studies 
    • Atypical drugs were only moderately better for type 2 symptoms 
    • Reviewed four studies involving atypical drugs
    • In 2 the drugs were slightly more effective
    • In 1 they were the same 
    • In 1 they were slightly worse
  3. What did McGlashan and Fenton find?
    • The catatonic subtype is very rare and could be caused by the anti psychotics that are taken 
    • It isn't a true subtype of schizophrenia and should be dropped as such
  4. What did Lieberman find?
    • Some people stay in the active phase for many years
    • In these cases type one symptoms in early years are replaced by type 2 symptoms later in life
  5. What did Kendler et al find?
    • First degree relatives of schizophrenics are 18x more likely to develop schizophrenia 
    • The national average is 1% likelihood
  6. What did Gottesman and Shields find?
    The more genetically similar you are to a schizophrenic, the more likely you are to be schizophrenic yourself

    • Person with:
    • Schizophrenic parent: 17%
    • Schizophrenic sibling: 9%
    • Schizophrenic sibling and parent: 12.9%
    • Schizophrenic parents: 46%
  7. What were the results of the 5 studies from 1969-1976?
    • Concordance rates for schizophrenia between:
    • DZ twins: 14%
    • MZ twins: 46%
  8. What did Heston find?
    Of 47 mothers with schizophrenia who's children were adopted within days of birth by typical mothers, the instance of schizophrenia was 16%
  9. What did Kety find?
    High rates of schizophrenia were found in people who's biological parents had it but who had been adopted by psychologically healthy parents
  10. What did Tienary find?
    • 155 adopted children with schizophrenic mothers were compared to a matched group with no family history of schizophrenia 
    • 10% in group 1 were schizophrenic
    • 1% in group 2 were schizophrenic
  11. What did Myakawa find?
    • Studied DNA of schizophrenics 
    • Affected seemed to have an affected gene PPP3CC- associated with the production of an enzyme 
    • GMO mice deprived of this gene displayed schizophrenic symptoms
  12. What did Wong et al find?
    • PET scans were carried out on the brains of schizophrenics 
    • A higher density of dopamine activity was recorded in schizophrenic brains than the control group
  13. What did Durand and Barlow find?
    • Serotonin plays a bigger part in schizophrenia
    • Serotonin is a master neurotransmitter that controls other neurochemicals such as dopamine 
    • New drugs such as clozapine that are more effective in reducing symptoms affect serotonin rather than dopamine
  14. What did Bateson find?
    • Parents communicate contradictory messages to their children 
    • They say one thing but their tone or gestures or tone communicate the opposite 
    • One message is conveyed on the verbal level but another is conveyed on the non verbal level
  15. What did Brown find?
    Schizophrenia development is augmented when someone is in a negative emotional climate
  16. What did Schiffman et al find?
    Expressed emotion is a stress factor possibly causing or contributing to the development of schizophrenia
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Schizophrenia Studies 1
2014-05-18 15:58:46

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