PHRD5935 Pharm/Tox Lecture 12 - Nephrotoxicity

Card Set Information

Author:
daynuhmay
ID:
274779
Filename:
PHRD5935 Pharm/Tox Lecture 12 - Nephrotoxicity
Updated:
2014-05-19 07:03:47
Tags:
Nephrotoxicity
Folders:

Description:
Nephrotoxicity
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user daynuhmay on FreezingBlue Flashcards. What would you like to do?


  1. general clinical findings in nephrotoxicity (6)
    • 1) inc BUN
    • 2) inc SCr
    • 3) dec GFR
    • 4) dec urinary output
    • 5)  in urinary sediment
    • 6) altered tubular fcn
  2. acute nephrotoxicity
    • inc in SCr by 50% w/in 7 days or
    • inc in SCr by 0.3mg/dL in 2 days or
    • oliguria (<400mL/day)
  3. chronic nephrotoxicity
    • GFR < 60mL/min/1.73 m2 for 3mos and/or 
    • kidney damage for >3mos
  4. estimated by methods that employ endogenous creatine
    GFR
  5. 6 categories of drug-induced nephrotoxicity
    • 1) pseudo-renal
    • 2) hemodynamic (pre-renal)
    • 3) glomerular
    • 4) tubular epithelial/acute tubular necrosis (ATN)
    • 5) interstitial nephritis
    • 6) obstructive (post-renal)
  6. drugs assoc'd w/ pseudo-renal nephrotox (4)
    • steroids
    • tetracycline
    • cimetidine
    • trimethoprim
  7. drugs assoc'd w/ hemodynamic nephrotox (3)
    • ACE inhibitors
    • NSAIDs
    • cyclosporin A
  8. drugs assoc'd w/ glomerular nephrotox (5)
    • gold
    • D-penicillamine
    • NSAIDs
    • hydralazine
    • bisphosphonates
  9. drugs assoc'd w/ tubular epithelial nephrotox (5)
    • aminoglycosides
    • radiocontrast media
    • cyclosporin A
    • anti-virals
    • cisplatin
  10. drugs assoc'd w/ interstitial nephritis nephrotox (4)
    • diuretics
    • abx
    • NSAIDs
    • PPIs
  11. drugs assoc'd w/ obstructive nephrotox (3)
    • amphotericin B
    • methotrexate
    • anti-virals
  12. characterized by inc BUN:SCr w/ maintenance of GFR
    pseudo-renal nephrotox
  13. characterized by proteinuria, edema, dec serum albumin due to urinary losses
    glomerular nephrotox
  14. common form of drug-induced nephrotox characterized by cellular degeneration & sloughing from proximal & distal tubules, and dilation of tubules
    acute tubular necrosis
  15. causes ATN w/ gradual inc SCr, dec serum Mg & K (wasting)
    aminoglycosides (abx)
  16. causes ATN w/ osmotic diuresis leading to tubular proteinuria, dec FeNa, inc SCr day2-5, oliguria
    radiographic contrast media
  17. if FeNa <1%
    prerenal
  18. if FeNa >1%
    intrinsic
  19. if FeNa >4%
    postrenal
  20. drug transporters play a role in length of exposure of the kidney to this drug that is used to treat cancers by forming intrastrand crosslinks w/ DNA
    cisplatin
  21. characterized by mononuclear cell infiltrate w/ edema in renal interstitium, w/ onset 17 days after initiating drug
    interstitial nephritis
  22. distension & dilation of renal pelvis, usually caused by obstruction of the free flow of urine from the kidney
    hydronephrosis
  23. characterized by pain, hematuria, crystals precipitating within tubules, ureter, or bladder
    obstructive (postrenal) nephrotox
  24. crystal-producing drugs (6)
    • indinavir
    • acyclovir
    • sulfonamides
    • methotrexate
    • triamterene
    • ciprofloxacin

What would you like to do?

Home > Flashcards > Print Preview