PHRD5925 Pharmaceutics Lecture 23 - Transdermal Delivery Systems

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daynuhmay
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274877
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PHRD5925 Pharmaceutics Lecture 23 - Transdermal Delivery Systems
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2014-05-20 06:46:16
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Transdermal Delivery Systems
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Transdermal Delivery Systems
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  1. how do you tell W/O & O/W emulsions apart?
    they feel like their continuous phase & disperse in the same continuous phase
  2. types of cells present in the epidermis (4)
    • 1) keratinocytes
    • 2) Langerhans cells
    • 3) Merkel cells
    • 4) melanocytes
  3. shape of cells from stratum corneum down to basal cells
    flat -> columnar
  4. type of lipids from stratum corneum down to basal cells
    neutral lipids -> sphingolipids -> phospholipids
  5. 2 things that make up the epidermal barrier (in brick-and-mortar model)
    • keratin-rich corneocytes
    • lipid matrix
  6. 3 routes of transdermal absorption
    • 1) intra-/transcellular
    • 2) intercellular
    • 3) shunt (pores, hair shaft)
  7. characteristics directly proportional to rate of transport
    • surface area
    • concentration difference
  8. characteristic inversely proportional to rate of transport
    thickness of membrane
  9. 2 things we can change to control drug absorption
    • particle size
    • charge/pH
  10. device that can determine how much of a drug is absorbed through the skin
    Franz cell
  11. permeability is inversely related to what 3 things?
    • 1) time
    • 2) surface area
    • 3) concentration
  12. intrinsic drug permeability is largely dictated by these 3 factors
    • 1) molecular size of the drug
    • 2) lipophilicity
    • 3) molecular charge
  13. Lipinski's Rule of 5
    • 5 H bond donors
    • 10 H bond acceptors
    • mass 500
    • partition coefficient 5
  14. an inert solid in which a drug is uniformly suspended
    matrix
  15. drug availability is controlled by
    dissolution in matrix up to saturation in the matrix
  16. component of transdermal drug delivery that contains drug & controls dissolution
    reservoir layer
  17. 4 types of transdermal patches
    • matrix
    • reservoir
    • microreservoir
    • drug-in-adhesive
  18. rate limiting step in all patches
    release liner
  19. cheapest, simplest patch design
    drug-in-adhesive
  20. 4 energy-driven methods of penetration enhancement
    • 1) ultrasound
    • 2) iontophoresis
    • 3) electroporation
    • 4) jet injection
  21. non-invasive method using voltage to push charged molecules through the skin
    iontophoresis

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