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Causes direct dilation of arterioles, increases contractility.
For treatment severe HTN if unresp to safer drugs
Side effects: Reflex tachycardia, Na+ and H2O retention (may need loop diuretics), hypertrichosis
Direct dilation of arterioles.
Side effects: orthostatic hypotension, systemic lupus erythematosus-like syndrome, reflex tachycardia, increased blood volume.
DDI with beta blockers and anti-HTN drugs
Vasodilator which releases nitric oxide, activates cellular cascade (similar to nitroglycerin)
For treatment of HTN emergencies (drug of choice)
Side effects: thiocyanate toxicity with prolonged use, cyanide poison if too fast, hypotension, reflex tachycardia
Sodium nitroprusside [Nipride]
- ACE inhibitors (e.g. captopril)
- Organic Nitrates (e.g. nitroglycerin)
- Calcium Channel Blockers (CCBs)
- Sympatholytics (alpha 1 antagonists, ie prazosin)