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Rxgirl007
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-
acetaminophen
- Tylenol
- MOA: inhibits synthesis of prostaglandins in the CNS and peripherally block pain impulse generation
- BBW: hepatotoxicity associated with intake >4 g/day
- 325 mg (max 2 Q4-6H) NTE 10 tabs per day
- 500 mg (max 2 Q6H) NTE 6 tabs per day
- 650 mg ER (max 2 tabs Q8H) NTE 6 tabs per day
- children's - 10-15 mg/kg Q4-6H, max 5 doses per day
- Infant - 160 mg/5mL (children's suspension)
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acetaminophen + hydrocodone
Vicodin, Norco, Lortab
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acetaminophen + oxycodone
Percocet, Endocet
-
acetaminophen + codeine
Tylenol #2, 3, 4
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acetaminophen + tramadol
Ultracet
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acetaminophen + diphenhydramine
Tylenol PM
-
-
acetaminophen antidote
- N-Acetylcysteine (NAC, oral and IV)
- MOA: restores intracellular glutathione
- given immediately
-
aspirin
- acetylsalicylic acid
- MOA: inhibits the activity of cyclooxygenase enzymes, binds irreversibly to block activity of thromboxane and prostaglandins
- BBW (3): CV, GI, CABG
- cardioprotection - 81-162 mg
- analgesic dosing - 325-650 mg
- overdose - tinnitus
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salsalate
- -
- MOA: similar to aspirin
- lower risk of GI tox
- overdose - tinnitus
- up to 3 grams/day divided BID - TID
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