ABSITE Ch2: Hematology

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Author:
khata
ID:
276431
Filename:
ABSITE Ch2: Hematology
Updated:
2014-06-08 22:51:35
Tags:
ABSITE
Folders:
ABSITE,Surgery
Description:
ABSITE review chapter 2
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  1. Three initial responses to vascular injury:
    • Vascular vasoconstriction
    • Platelet adhesion
    • Thrombin generation
  2. Intrinsic pathway:
    • Exposed collagen + prekallikrein + HMW kininogen + factor XII -> 
    • XI ->
    • IX + VIII ->
    • Prothrombin to thrombin ->
    • Fibrinogen to fibrin
  3. Extrinsic pathway:
    • Tissue factor (injured cells) + factor VII ->
    • X and V ->
    • Prothrombin to thrombin ->
    • Fibrinogen to fibrin
  4. Prothrombin complex
    • X, V, Ca, platelet factor 3, and prothrombin
    • Forms on platelets
    • Catalyzes the formation of thrombin
  5. Antithrombin III
    • Key to anticoagulation
    • Binds and inhibits thrombin
    • Inhibits factors IX, X, and XI
    • Activated by heparin

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