Infections in pregnancy
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Cytomegalovirus - CMV
2. Foetal/neonatal effects: asymp and symp at birth
1. Herpes virus, requires personal contact. Common cause of childhood handicap and deafness.
- 2. Vertical transmission - 40%
- - 10% symptomatic at birth: IGUR, pneumonia and thrombocytopenia; severe neurological sequela e.g. hearing, visual and mental impairment.
- - asymptomatic at risk of deafness
- 3. - Ultrasound abnormalities: intracranial and hepatic calcification in only 20%
- - Maternal infections is confirmed, amniocentesis at least 6/52 after maternal infection -> confirm or refute vert trans
- 4. - Most infected neonates are not seriously affected
- - Close surveillance for US abnormalities and fetal blood sampling at 32/40 for fetal platelet levels - determine those at most risk
- - no prenatal treatment
- - no routine treatment, no vaccinations
Infections suitable for screening: 3 certain, 3 probably
- Hep B
- - Chlamydia
- - Bacteria vaginosis
- - beta-haemolytic streptococcus
- - CMV (cytomegalovirus)
- - Rubella
- - Toxoplasmosis
- - Syphilis
- - Herpes Zoster
- (con rua to nhu meo so hai)
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