- most common agent is bactrium
- combo drug- Sulfamethoxazole and trimenthoprim)
MOA- block folic acid and then u can't make RNA and DNA unable to replicate
two drugs block the formation of folic acid in two different places
most common SE hypersensitivity- rash pt turns bright pink, photsensitivity, anemia, crystaluria- crystal in urine- forms when urine is more acidic u want this to more alkaline (push fluids) also NA bicard tabs , nephrotox.
- NI: bun.creatin- sunscreen, admins 1 hr before or 2 hrs after admin to decrease GI upset
- dont give with antacid