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Prittyrick
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Drugs used to treat UTI
Sulfinamides- bactruim
Antiseptic agents- decrease bacterial growth
Urinary Analgesic- helps to reduce
Other agents- Peni, cephral, aminoglycides, fluroquinolones,
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Sulfonamides
- most common agent is bactrium
- combo drug- Sulfamethoxazole and trimenthoprim)
Broad spectrum
MOA- block folic acid and then u can't make RNA and DNA unable to replicate
two drugs block the formation of folic acid in two different places
most common SE hypersensitivity- rash pt turns bright pink, photsensitivity, anemia, crystaluria- crystal in urine- forms when urine is more acidic u want this to more alkaline (push fluids) also NA bicard tabs , nephrotox.
- NI: bun.creatin- sunscreen, admins 1 hr before or 2 hrs after admin to decrease GI upset
- dont give with antacid
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Urinary Antiseptic Agents
Ex- Macrodantin
CI local effect in the urine
MOA- block the enzyme needed for Carborhydrates so the cell doesn;t have any energy and it dies. blocks energy source
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Urinary Antiseptic Macrodantin spectrum, SE NI
Broad spectrum- acute or reoccurence UTI
SE: GI-, peripheral neuropathy, superinfection, hypersensitivity
- NI: admin with food decrease upset
- change urine to brown
- suprainfection
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Urinary Analgesics
Ex: Pyridium
CI: local in urinary tract
MOA- unknown
it is well tolerated
Urine bright orange-to red colors
used to reduce pain no antimoribial
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Antifungal agent
alter cell permeability, allows cell contents to fall out
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Nystatin (easy)
- local effect
- topical- on the skin
- in the mouth- swish and spit
- in throat- swish and swallow (in esophagus)
works best on contact. the longer u keep it in the mouth it works
SE: few
NI swish
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Fluconazole (if Nystatin doesn't work)
Esophaheal/oropharnyngeal infections
mouth and throat - not being cleared with Nystatin
Specturm wide- can be used for systemic infection
SE- GI, increase liver enzyme, and renal function
NI: take with food and monitor renal and liver function
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Amphotericin B (if Fluconazole doesn't work)
antifugal agents
- drug of choice for severe systemic fungal infections (life threatening)
- SE: nephrotoxic, renal function watch,
- IV low slowly pump- monitor for 15 mins- pt present with a fever, chills, headache
- pretreat them to decrease the sign of allergy ie benadryl
- assess CBC
- BUN/creatinine
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