NAPLEX Class Infectious Diseases

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Author:
HUSOP2014
ID:
277330
Filename:
NAPLEX Class Infectious Diseases
Updated:
2014-06-21 21:01:58
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Class MOA SE
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Description:
Drug classes testing MOA, SE, BB
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  1. Penicillin
    • MOA: Cell wall inhibitor, ¬†Beta-lactam-I (Cidal)
    • SE: N/V/D, nephritis
    • PREG: B
  2. Cephalosporins
    • MOA: Cell wall inhibitor, Beta-lactam-I (Cidal)
    • SE: N/V/D, nephritis, seizures
    • PREG: B
  3. Aminoglycosides
    • MOA: protein synthesis I, 30s 50s ribosomal subunits (Cidal)
    • SE: Nephrotoxicity, Hearing loss,¬†
    • BBW: Neurotoxxicity, nephrotoxicity
    • PREG: D
  4. Carbapenems
    • MOA: Cell wall inhibitor, Beta-lactam-I (Cidal)
    • SE: D, rash, seizures
    • PREG: B / C(imipenem)
  5. Fluoroquinolones
    • MOA: Topoisomerase IV-I, DNA gyrase-I (Cidal)
    • SE: QT prolongation, peripheral neuropathy, seizures (CNS), Hypoglycemia, Photosensitivity, Hepatotoxicity
    • BBW: Tendon rupture
    • PREG: C
  6. Macrolides
    • MOA: Protein synthesis-I, 50s ribosomal subunit (Static)
    • SE: QT prolongation, Hepatotoxicity, Ototoxicity, GI upset
    • PREG: B/ C(clarithromycin)
  7. Tetracyclines
    • MOA: Protein synthesis-I, 30s Ribosomal (Static)
    • SE: GI upset, Photosensitivity, rash, Lupus-Like Syndrome, bone marrow supression
    • BBW: children <8yo
    • PREG: D
  8. Sulfonamide
    • MOA: (Static) dihydrofolic acid-I
    • SE: GI upset, SJS, crystalluria, photosensitivity, hypokalemia, hypoglyccemia, QT prolongation
    • BBW: Pregnancy at term
    • PREG: C/D at term
  9. Glycopeptide- Vancomycin
    • MOA: (Cidal) glycopeptide-I cell wall
    • SE: GI upset, Red-man syndrome, Nephrotoxicity, Bone marrow suppression, ototoxicity
    • PREG: B oral/ C IV
  10. Oxazolidinone- Linezolid
    • MOA: (Static) 23s ribosomal 50s subunit-I
    • SE: Myleosuppression, neuropathy, serotonin syndrome, Hypoglycemia, HA, D
    • BBW: use with MAO-I
    • PREG: C
  11. Streptogramin- Quinupristin/Dalfopristin
    • MOA: (Cidal) 50s ribosomal subunit-I
    • SE: Myalgias (47%), infusion reaction (44%), Phlebitis (40%), hyperbilirubinemia (35%), GI upset
    • PREG: B
  12. Lipopeptide- Daptomycin
    • MOA: (Cidal) depolarization membrane intracellular replication-I
    • SE: Myopathy, GI upset, CNS, hypo/er-Kalemia
    • PREG: B
  13. Lipoglycopeptide- Telavancin
    • MOA: peptidoglycan cross-link-I
    • SE: QT prolongation, Red-man-S, Nephrotoxicity, N/V, metallic taste
    • PREG: C
  14. Monobactam- Aztreonam
    • MOA: (Cidal) cell wall synthesis cross-link-I
    • SE: rash, D/N/V,
    • PREG: B
  15. Polymyxin- Colistimethate
    • MOA: (cidal) cationic detergent damaging cell membrane
    • SE: Nephrotoxicity, CNS,
    • PREG: C
  16. Chloramphenicol
    • MOA: 50s ribosomal subunit-I (Cidal)
    • SE: Gray syndrome, Myelosuppression, urticaria
    • BBW: Aplastic anemia, fatal blood dyscrasias
    • PREG: C
  17. Ketolide- Telithromycin (Ketek)
    • MOA: (Cidal) 50s ribosomal-I
    • SE: Hepatic filure, QT prolongation, Visual, GI upset,CNS, rash
    • BBW: Do not use in Myasthenia Gravis
    • PREG: C
  18. Glycylcyclines- tigecycline (Tygacil)
    • MOA: (static) 30s ribosomal-I
    • SE: Hepatotoxicity, Pancreatits, Photosensitivity, GI, CNS,rash
    • BBW: DEATH-last resort, not < 8yo
    • PREG: D
  19. Lincomycin- Clindamycin (Cleocin)
    • MOA: (Static) 50s ribosomal-I
    • SE: GI upset, urticaria, SJS
    • BBW: colitis- possibly fatal
    • PREG: B
  20. Metronidazole (Flagyl)
    Tinidazole (Tindamax)
    • MOA: (Cidal) DNA helical structure breakage
    • SE: GI, CNS (seizures, encephalopathy), metallic taste, glossitis, darkened urine, rash
    • BBW: Possibly carcinogenic
    • PREG: Metro= B/ CI-1st trimester, Tinid=C/CI-1st trimester
  21. Rifaximin (Xifaxan)
    • MOA: (Cidal) Binds DNA-dependent RNA polymerase
    • SE: Flatulence, GI, rash
    • PREG: C
  22. Fosfomycin (Monurol)
    • MOA: (Cidal) Pyruval transferase-I (cell wall)
    • SE: HA/D/N
    • PREG: B
  23. Nitrofurantoin (Macrodantin, Macrobid, Furadantin)
    • MOA: (Cidal) cell wall-I
    • SE: N,HA, hepatotoxicity, neuropathy, Brown urine, Pulmonary toxicity
    • CI: CrCl<60
    • PREG: B/ CI at term
  24. Fidaxomicin (Dificid)
    • MOA: (Cidal) RNA polymerase-I
    • SE: N/V, GI bleeding, anemia
    • PREG: B
  25. Amphotericin B
    • MOA: (Cidal) Binds ergosterol-membrane permeability
    • SE: Flu-like symptoms, nephrotoxicity, Anemia, N/V, HA
    • BBW: Errors administration of Lipid/conventional dosing
    • PREG: B
  26. Flucytosine (Ancobon)
    • MOA: converted to 5FU
    • SE: CNS, hepatitis, Bone marrow suppression, Aplastic Anemia
    • BBW: Renal dysfunction, hepatic status
    • PREG: C
  27. Azole Antifungals
    • MOA: ergosterol synthesis-I cell membrane
    • SE: QT prolongation, HA, N/V/ LFTs, CNS,
    • BBW: QT prolongation, hepatotoxicity, 3A4 substrates
    • PREG: C/ D-voriconazole
  28. Echinocandins
    • MOA: Beta(1,3)-D-glucan synthesis-I, cell wall
    • SE: N/V/D, LFTs, Hypo (K, Mg, tension)
    • PREG: C/ B (anidulafungin)
  29. Griseofulvin (Griffulvin, Gris-PEG)
    • MOA: binds keratin percursor cells (stops invasion)
    • SE: HA, rash, photosensitivity, LFTs, Agranulocytosis, severe skin reations
    • CI: liver disease, porphyria, pregnancy
    • PREG: X
  30. Terbinafine (Lamisil)
    • MOA: squalene epoxidase-I (cell wall)
    • SE: HA, D, rashes,LFT, loss of taste
    • PREG: B
  31. NRTIs Class
    • MOA: inhibit viral replication
    • SE: N/V, LFTs, CBC
    • BBW: Lactic acidosis, hepatomegaly
  32. NNRTI class
    • MOA: inhibits viral replication
    • SE: Rash (SJS, TEN), Hepatotoxicity
  33. PI class
    • MOA: renders immature noninfectious virions
    • SE: Hyperglycemia, hyperlipidemia, fat maldistribution, hepatitis
    • CI: DDI: 3A4 inhibitors
  34. Fusion I (Enfuvirtide- Fuzeon)
    • MOA: gp41 conformational change-I for CD4 cell entry
    • SE: Injection reaction, risk bacterial pneumonia
  35. CCR5 Antagonist (Maraviroc- Selzentry)
    • MOA: CCR5-I on CD4 cell preventing entry
    • SE:URTI, rash (SJS), hepatotoxicity, musculoskeletal symptoms.
    • CI: CrCl< 30 w 3A4 inhibitors/inducers
    • BBW: hepatotoxicity
  36. Intergrase Strand Transfer Inhibitors (INSTIs)
    • MOA: Integrase-I, blocks viral DNA from nucleus entry
    • SE: insomnia, N/V/D, HA, rash
    • BBW: Elvitegravir (stribild)-lactic acidosis with severe hepatomegaly

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