NAPLEX Drugs that cause notable SE.

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HUSOP2014
ID:
277583
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NAPLEX Drugs that cause notable SE.
Updated:
2014-06-25 13:57:36
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HUSOP drug induced reactions
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Description:
drugs that cause BG, K, QT prolongation, CYP inhibition/inducing effects, etc.
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  1. P-Glycoprotein (P-gp) Inhibitors:
    Partial list
    • Itraconazole, Ketoconazole
    • Indinovir, Lopinovir, Ritonavir
    • Clarithromycin, Erythromycin
    • Amiodarone
    • Verapamil
    • Quinidine
    • Conivaptan
  2. P-Glycoprotein (P-gp) Inducers:
    Partial list
    • Rifampin
    • Avasimibe
    • Carbamazepine
    • Phenytoin
    • St. John's Wort
    • Tipranavir/Ritonavir
  3. Notable P-gp substrates:
    partial list
    • Digoxin
    • Dabigatran, Rivaroxaban
    • Cyclosporine, Tacrolimus
    • Colchicine
    • Aliskiren
    • Fexofenadine
    • Posaconazole
    • Ranolazine
    • Saxagliptin
  4. CYP 3A4 Inducers:
    • Oxcarbazepine
    • Carbamazepine
    • Phenytoin
    • Pheonbarbital
    • Primidone,
    • Rifabutin, Rifampin, Rifapentin,
    • Smoking
    • St. John's Wort
  5. CYP 3A4 Inhibitors:
    Partial list
    • Amiodarone, Dronedarone,
    • Diltiazem, verapamil
    • Cimetidine
    • Clarithromycin, Erythromycin, telithromycin
    • Fluconazole, itraconazole, Ketoconazole, Posaconazole, Voriconazole
    • Protease Inhibitors
    • Grapefruit juice
    • Sertraline, Fluvoxamine, Haloperidol,
    • Isoniazid
  6. Big CYP Inducers:
    • PS PORCS:
    • Phenytoin
    • Smoking
    • Phenobarbital
    • Oxcarbazepine
    • Rifampin (rifabutin, rifapentine)
    • Carbamazepine
    • St. John's Wort
  7. Big CYP Inhibitors:
    • G-PACMAN
    • Grapefruit
    • PIs Prtease inhibitors
    • Azole antifungals
    • Cyclosporine, Cimetidine
    • Macrolides (not Azithromycin0
    • Amiodarone and dronedarone
    • Non-DHP CCB Diltiazem and Verapamil
  8. Drugs that can cause Serotonin Syndrome if used concomitantly:
    • MAOs
    • SSRIs
    • SNRIs
    • TCAs
    • Triptans
    • tramadol, Mirtazapine, Cyclobenzaprine, bupropion, buspirone, linezolid, lithium, meperidine, St. John's Wort, Dextromethorphan, others
  9. Drugs that increase bleeding risk if used concomitantly:
    • Anticoagulants
    • Antiplatelets
    • NSAIDs
    • SSRIs, SNRIs,
    • Ginkgo Biloba, Vit E, Fish Oil, Garlic, Glucosamine, Grapefruit, Evening primrose oil, willow bark, wintergreen oil
  10. Drugs that increase risk of Hyperkalemia:
    • Aldosterone antagonists
    • ACEIs, ARBs, aliskiren,
    • amiloride,
    • Calcineurin Inhibitors
    • Trimethoprim (in Bactrim)w sulfamethoxazole
  11. Drugs that cause CNS depression:
    • Alcohol,
    • Opioids
    • Skeletal muscle relaxants,
    • anticonvulsants
    • Benzodiazepines,
    • Barbiturates
    • Hypnotics, mirtazapine, trazadone, propranolol, clonidine
  12. Drugs that cause QT prolongation:
    • AntiArrhythmics
    • Quinolones
    • Macrolides
    • Azole antifungals
    • PI protease inhibitors
    • TCAs, SSRIs, SNRIs
    • 5HT3 antagonists (setrons)
    • Antipsychotics (thioridazines- chlorpromazine, haloperidol, ziprasidone, risperidone, patiperidone, iloperidone, quetiapine, clozapine, 
    • quinine, chloroquine,apomorphine, methadone, alfuzosin, ranolaxine, galantamine,
  13. Drugs that cause Ototoxicity:
    • Salicylates
    • Aminoglycosides
    • Vancomycin,
    • Loop diuretics
    • Cisplatin
    • Mefloquine
  14. Drugs that should not be used in Severe Renal Impairment (CrCl<30):
    partial list
    • Bisphosphonates
    • NSAIDS
    • Lithium
    • Metformin
    • Nitrofurantion
    • K sparing diuretics
    • Dabigatran, Fondaparinux, Rivaroxaban
    • Glyburide
    • Tramadol ER
    • Voriconazole
    • Meperidine
    • Tadalafil, Tenofovir, Cidofovir,
  15. Drugs to be flushed down toilet to avoid accidental use (FDA approved list):
    • Oxycodone in most forms
    • Buprenorphine, Methadone
    • Hydromorphone, Morphine
    • Methylphenidate
    • Diazepam
    • Fentanyl
    • Meperidine, Tapentadol
  16. Antibiotic suspensions NOT to refrigerate:
    • Azithromycin, Clarithromycin
    • Cefdinir, Cefixime
    • Clindamycin
    • Ciprofloxacin, Levofloxacin
    • Doxycycline
    • Linezolid
    • Fluconazole, Voriconazole
  17. Antibiotics that do NOT require renal dose adjustments:
    • Azithromycin, Clindamycin, Erythromycin, 
    • Ceftriaxone
    • Nafcillin, Oxacillin, Dicloxacillin
    • Chloramphenicol
    • Doxycycline, Minocycline, Tigecycline
    • Fidaxomicin, Linezolid, Metronidazole
    • Moxifloxacin, Rifaximin, Rifampin
    • Quinupristin/dalfopristin
    • Tinidazole
  18. Drugs that cause alter BG- Hyperglycemia:
    • Corticosteriods
    • PIs
    • Atypical antipsychotics (olanzapine, clozapine, quetiapine)
    • Thiazide and loop diuretics
    • Statins and niacin
    • Fluoroquinolones
    • Beta-Agonists
    • Carvedilol, Propranolol (other BB possible)
    • Cyclosporine, Tacrolimus
    • Interferons
  19. Drugs associated with Drug-Induced Lupus:
    • Procainamide
    • Hydralazine
    • Isoniazid
    • Quinidine
    • Methyldopa
    • Propylthiouracil
    • Methimazole
    • Terbinafine
    • Anti-TNF agents
  20. Drugs associated with Hypothyroidism:
    • Amiodarone,
    • interferons,
    • lithium
    • nitroprusside,
    • Tyrosine Kinase Inhibitors (Sunitinib)
  21. Drugs associated with osteoporosis risk:
    • Steroid use long term
    • Depot Medroxyprogesterone acetate
    • Anticonvulsants
    • Warfarin and Heparin
    • Loop diuretics
    • Aromatase inhibitors
    • Nfarelin
    • Adrogen blockers
    • PPI
  22. Drugs that increase risk of uric acid (Gout):
    • Thiazide and loop diuretics
    • Niacin
    • Aspririn high dose
    • Pyrazinamide
    • Cyclosporine
    • Tacrolimus
  23. Drugs that can worsen HTN:
    • ACTH
    • Alcohol
    • Amphetamines
    • Appetite suppressants, Caffeine
    • Calcineurin antagonists
    • Corticosterioids
    • Decongestants
    • erythropoietin
    • Estrogen
    • NSAIDs
    • Oncology drugs
    • SNRIs
    • Thyroid hormone
    • Herbals: bitter orange, ephedra, ginseng, guarana, St. John's Wort
  24. Drugs associated with Hyperlipidemia (LDL):
    • Diuretics
    • Cyclosporine, Tacrolimus
    • Glucocorticoids
    • Amiodarone
  25. Drugs that can worsen Heart Failure:
    • Some chemotherapeutic agents
    • Amphetamines/sympathomimetics
    • CCB in systemic HF
    • Anti-Arrhythimics (low risk with amiodarone and dofetilide)
    • Itraconazole
    • Immunomodulators,(Interferons, TNF-I, rituximab others
    • NSAIDS, especially COX-2-I
    • Glucocorticoids
    • Triptans
    • Thiazolidinediones rosi, pioglitazone
    • Excessive Alcohol
    • Ergot derivatives
  26. Drugs that can trigger an Asthma attack:
    • Aspirin
    • NSAIDs
    • Sulfites
    • Beta-Blockers (non-selective)
  27. Drugs that can worsen depression:
    • Beta-Blockers
    • Clonidine
    • Corticosteroids
    • Cyclosporine
    • Interferons,
    • Oral contraceptives
    • Statins,
    • Varenicline
    • Isotretinoin, indomethacin, procainamide, Reserpine
    • Methadone, opioid use
    • Methylphenidate other stimulants
  28. Drugs that can cause Psychotic symptoms:
    • Amphetamines (stimulants),
    • Methamphetamine
    • Cannabis
    • Cocaine
    • Dextromethorpan
    • Anticholinergics
    • Dopamine agonists
    • Interferons
    • Steroids
    • Phencyclidine (PCP)
    • Lysergic acid diethylamide (LSD)
  29. Drugs that can worsen Dementia:
    • anticholinergics
    • Antihistamines
    • Antipsychotics
    • Barbiturates
    • Benzodiazepines
    • skeletal muscle relaxants
    • other CNS depressants
  30. Drugs that can worsen anxiety:
    • Theophylline, Caffeine
    • Levothyroxine
    • Acetazolamide
    • Albuterol
    • stimulants
    • Decongestants (pseudoephedrine)
    • Steroids
    • Bupropion, Fluoxetine, Paroxetine
    • Cocaine, LSD, Methamphetamine others
  31. Drugs that contribute to insomnia:
    • Bupropion, Fluoxetine
    • Stimulants
    • Decongestants
    • MAO-B inhibitors
    • Caffeine
    • Steroids
    • Alcohol
    • drugs that cause nocturia- diuretics
  32. Drugs that lower Seizure Thresholds:
    • antipsychotics (pheno-thiazines, clozapine)
    • Bupropion,
    • Penicillins
    • Carbapenems
    • cephalosporins
    • Fluoroquinolones
    • lindane, lithium, theophylline
    • Mefloquine, Meperidine, Metoclopramide
    • Evening primrose oil, ginko, melatonin
    • Alcohol
    • infection, fever
  33. Drugs that cause Constipation:
    • Opioids
    • Anticholinergics
    • Antihistamines,
    • TCAs
    • Non DHP CCB
    • Clonidine
    • Tramadole, tapentadol
    • Colesevelam
    • Iron, Aluminum, Bismuth
    • Varenicline, aripiprazole, phentermine, topiramate
  34. Drugs that cause Erectile Dysfunction:
    • Beta-Blockers, Clonidine
    • Antipsychotics
    • SSRIs, SNRIs, TCAs(less)
    • BPH drugs finasteride, dutasteride
    • chemotherapy drugs
    • Cimetidine
    • Opioids, Methadone
    • Nicotine
  35. Drugs that worsen BPH:
    • Decongestants
    • Anticholinergics
    • Antihistamines
    • TCAs, SNRIs
    • Caffeine
    • Diurectics
    • Testosterone
  36. Drugs that increase Intraocular Pressure/Glaucoma:
    • antihistamines
    • Anticholinergics
    • Corticosteroid chronic use
    • Topiramate
  37. Drugs that cause Photosensivity Reactions:
    • Loop diuretics, HCTZ
    • Tetracyclines, Fluoroquinolones, Sulfonamides
    • NSAIDs
    • Retinoids
    • Sulfonylurias
    • Statins
    • Antifungals
    • Amiodarone, quinine, Diltiazem,
    • others

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