Cell Phys Chapter 4

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Author:
hollyerichsen
ID:
279149
Filename:
Cell Phys Chapter 4
Updated:
2014-07-21 09:38:48
Tags:
Cell Phys
Folders:
Science
Description:
Chapter 4 Cell Phys
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  1. Binds G-actin monomers, preventin polymerization
    Profilin
  2. Breaks F-actin into smaller segments by twisting action
    Cofilin
  3. Fragment F-actin, requires calcium
    Gelsolin
  4. Cross-linking actin-binding protein
    Spectrin
  5. Extremely important to the structure of an RBC
    Spectrin
  6. Links actin to the basement membrane of skeletal muslces
    Dystrophin
  7. Gives muscle tensile strength
    Dystrophin
  8. Genetic defect in this results in muscular dystrophy
    Dystrophin
  9. Other types of filaments
    Inermediate filaments
  10. Intermediate filament structure
    Rope-like dimer claled a coiled-coil
  11. 2 coiled-coils associated together to form a
    Tetramer
  12. 8 tetramers are associated together to form a
    Single intermediate filament
  13. Energy needed to build an intermediate fiber
    None
  14. Required for movement of chromosomes during division
    Microtubules
  15. Necessary for intracellular transport
    Microtubules
  16. Synthesis of microtubules requires
    Energy (GTP)
  17. Microtubules regulated by
    Centerosomes
  18. Protofilaments
    linear chain of heterodimers
  19. 13 protofilaments join in
    Hollow ring structure
  20. Length of protofilaments varies based on
    Polymerization status and fuction
  21. New dimers are added to protofilaments where?
    At the GTP cap (Prior to hydrolysis of GTP to GDP)
  22. Protofilaments are part of
    The microtubule structure
  23. Microtubule disassembly occurs when
    Dimer addition slows and GTP cap is lost
  24. Loss of the GTP cap of a microtubule prevents
    New dimers from binding
  25. Loss of GTP cap prevents new dimers from binding, as well as
    Causes instability (peeling of protofilaments)
  26. Microtubule function
    • Chromosomal movement
    • Cilia and flagella
    • Intracellular movement
  27. Responsible for push and pull of chromosomes in dividing cells
    Microtubule
  28. Necessary for cells to move in fluid (epithelial cells of the respiratory tract)
    Cilia
  29. Required to move an entire cell through fluid
    Flagella
  30. Microtubule binding rotein necessary for movement of cilia
    Dynein
  31. Organelle rsponsible for movement of oraganelles or vesicles
    Microtubule
  32. Required for intracellular movement
    Dynein or kinesin (microtubule motor proteins)

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