systemic pharm nbeo4.txt
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What nucleotide synthesis blockers are there?
What sulfonamides are there?
What are sulfonamides used for?
- UTIs when used with trimethoprim
- Toxoplasmosis (sulfadiazine+ pyrimethamine)
What sulfonamide is used to treat toxoplasmosis?
Sulfadiazine + pyrimethamine
What are major adverse effects of sulfonamides?
- Myopic changes
- Contraindicated in preggers
What is polymixin B comprised of?
Polymixin B + trimethoprim
What are major adverse effects of trimethoprim?
- Aplastic anemia
- Bone marrow suppression
What is the mode of action of penicillins and cephalosporins?
- Cell wall synthesis blockers
- With b-lactam ring
- Works directly on peptidoglycan through inhibition of transpeptidase
What are major adverse effects of PCN and cephalosporins?
- Acute Hypersensitivity (type 1 reactions) (15% chance)
- Dermatitis (type 4 reaction)
- Voided oral contraceptives effect
What gram type do natural penicillins affect?
What do natural penicillins treat?
What gram type do amino penicillins affect?
Gram + and wider spectrum into gram (-)
What do amino penicillins treat?
- Otitis media
- H. influenzae (respiratory)
What amino penicillins are there?
What is Augmentin made out of?
Amoxicillin + clavulanic acid
What type of penicillins are not resistant to penicillinase?
What amino penicillin is a penicillinase inhibitor?
What PCN is IM or IV only?
What do penicillinase resistant penicillins treat?
- Narrow spectrum
- Staph aureus
- Staphylococcus epidermidis
What is the major adverse effect with methicillin?
Can cause interstitial nephritis
What PCN treats orbital cellulitis?
What PCN is used in eyelid infections such as hordeolums and blepharitis?
What are contraindications of cephalosporins?
What cephalosporin is a 1st generation?
What is cephalexin used for?
- Skn infections
- Preseptal cellulitis
What cephalosporin is a 2nd generation?
What cephalosporin is a 3rd generation?
What is ceftriaxone used for?
- DOC for gonorrhea (IM)
What drugs are used for TB?
- Remember RIPE cheese
Which TB drug is the only one that can be used in isolation?
What type of necrosis is found in TB?
What type of necrosis is found in heart diseases?
What drug is used to treat malaria?
What drug is used to treat scabies and lice?
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