systemic pathology nbeo.txt
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What is the immediate response 1-2 minutes after injury?
What do leukocytes do?
Help clear the injury site of invading bacteria
What inflammatory cells are mononuclear?
- Plasma cells
What events affect wound healing?
- Local infection
- Decreased blood supply such as in diabetes
- Immunocompromised states
- Systemic infection
- Increased stress
What is a type I hypersensitivity reaction
What immuno cells are involved with Type 1 hypersensitivity reactions?
What happens on a cellular level during a type 1 hypersensitivity reaction?
Histamine is released from mast cells and basophils
What are examples of type 1 hypersensitivity reactions?
What is the name for type 2 hypersensitivity reactions?
What immuno cells are involved with type 2 hypersensitivity reactions?
What happens on a cellular level during a type 2 hypersensitivity reaction?
Antigens are bound by IgM/G
What are some examples of type 2 hypersensitivity reaction?
- Rh dz
- Goodpastures syndrome
- Rheumatic fever
- Ocular cicatrical pemphigoid
What is the name for type 3 hypersensitivity reactions?
What immuno cells are involved in type 3 hypersensitivity reactions?
What are some examples of type 3 hypersensitivity reaction?
What is the name for type 4 hypersensitivity reactions?
What immuno cells are involved in type 4 hypersensitivity reactions?
What are some examples of type 4 hypersensitivity reactions?
- TB skin test
- Contact dermatitis
- Corneal transplant rejection
- Affects skin, kidneys, joints and heart
- Mostly in females 20s-30s
What are the S&S in lupus?
- Butterfly rash
- Renal disorders
- Neurological disorders
- Immunological disorders
- Hemolytic anemia
- Disc edema
What lab test should be run to determine lupus?
- Affects joints mostly, destruction of articular cartilage
- Symptoms are worse in the morning
- Women >men 40s-50s
- Life expectancy is reduced by 4-10 years
- Summarize Juvenile RA:
- Most common cause of uveitis in children
- Bilateral, nongranulomatous anterior uveitis
What is the triad of sjogren's syndrome?
- Dry mouth
- Dry eyes
What ocular manifestation can be seen with gout?
What demographic is more likely to have celiac sprue?
Northern European decent
What test should be performed for sarcoidosis?
- Chest x-ray
- Bells palsy testing
- Increased levels of ACE in blood serum
What are ocular signs of sarcoidosis?
- Anterior uveitis - Mutton-fat KP
- Posterior uveitis - candle-wax drippings
What does deficiency of IgA cause?
- Most common immunodeficiency
- Involved in mucosal defenses
- Recurrent respiratory tract infections
- Keratinization of the cornea
- Weight loss and diarrhea
What do you need to know about IgA?
Found in tears, saliva, breast milk
What do you need to know about IgD?
Activates B cells, mast cells, basophils
What do you need to know about IgE?
- Type 1 hypersensitivity reactions
- Surface of mast cells
- Parasitic worms
What do you need to know about IgG?
- Secondary response
- Crosses placental barrier
What do you need to know about IgM
- Primary response
- Surface of immature B cells
- ABO blood type
At what CD4 count does HIV become AIDS?
What CD4 count is associated with cytomegalovirus retinitis?
What are common opportunistic fungal infections occur with HIV/AIDS?
What are common opportunistic bacterial infections occur with HIV/AIDS?
- Mycobacterium tuberculosis
What are common opportunistic viral infections occur with HIV/AIDS?
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