Human diseases - Bacteria

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  1. Streptococcus pyogenes
    "flesh eating bacteria" that produces an endotoxin known as a super antigen that activates T cells and causes the overproduction of cytokines
  2. Staphylococcus
    • INVASIVE gram positive cocci that resemble a bunch of grapes
    • they cause pus forming diseases in humans
    • normally found in respiratory system and skin
    • can cause disease in many organs
  3. S. Aureus
    • Toxic Shock Syndrome
    • bacterial TSST - 1 protein binds to MHC class 2 and TCR
    • TOXIN stimulates T cell responses in the absence of a specific peptide
    • Cytokine overproduction (shock due to circulatory collaps and organ failure
  4. Methicillin - Resistant S. aureus (MRSA)
    • many strains are drug-resistant
    • MRSA strains typically acquired as nosocomial infections
  5. what is critical for reducing MRSA in health care settings?
    good aseptic techniques
  6. what causes antibiotic associated colitis?
    when antibiotic use kills normal flora and Clostridium Difficile take over in the gut. this leads to toxin production and sporulation
  7. what are the signs and symptoms of clostridium difficult?
    colitis, toxic megacolon, can lead to sepsis and death
  8. what is a novel approach to treating C. Diff?
    transplant of normal bacteria from another person delivered into the colon ("bacteriotherapy" or "fecal transplantation")
  9. What bacteria causes tuberculosis?
    mycobacterium tuberculosis
  10. what are commonly infected groups of TB (tuberculosis)?
    homeless, alcoholics, prisoners, immigrants
  11. at what pace does TB progress?
  12. how is TB transmitted?
    reactivation of old dormant infections
  13. what are virulence factors of Mtb?
    • unique toxic cell envelope components
    • Survive phagocytosis
  14. what is the course of disease for TB?
Card Set:
Human diseases - Bacteria
2014-07-29 06:05:15

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