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ABSITE Ch 4: Immunology
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What do helper T cells do?
Release IL-2 -> matures cytotoxic T cells
Release IL-4 -> Matures B-cells (plasma cells)
Involved in delayed-type hypersensitivity
What do suppressor T cells do?
Regulate CD4 and CD8 T cells
What do Cytotoxic T cells do?
Recognize and attack non-self antigens attached to MHCI
MHC Class I
a) Recognized by?
b) Present on which cells?
c) How many chains?
a) CD8 - cytotoxic T cells
b) Present on all nucleated cells
c) single chain with 5 domains
MHC class II
a) Recognized by?
b) Present on which cells?
c) How many chains?
a) CD4 - T helper cells
b) Present on antigen-presenting cells
c) 2 chains with 4 domains eack
Natural killer cells function?
Recognize cells that lack self MHC (class I), part of immunosurveillance for cancer
IgM
Initial Ab made after first exposure
5 domains
IgG
Secondary immune response
Crosses placenta
1 domain
Which Ab crosses the placenta?
IgG
Which Ab is secreted?
IgA
IgA
Found in secretions and breast milk
2 domains
IgD
Membrane bound receptor on B cells
Which Ab are opsonins?
IgM
IgG
Which Ab fix compliment?
IgM
IgG
What does the variable region of an Ab do?
Recognized Ag
What does the constant region of an Ab do?
Recognized by target cells (for opsonization, etc)
Type I hypersensitivity?
Immediate hypersensitivity reaction
Eosinophils and IgE -> mast cells and basophils
Type II hypersensitivity?
IgG or IgM interact with cell-bound antigen
Type III hypersensitivity?
Immune complex deposition
Type IV hypersensitivity?
Delayed-type hypersensitivity - antigen stimulation of previously sensitized T cells
Major source of histamine in the blood?
Basophils
Major source of histamine in the tissues?
Mast cells
Primary lymphoid organs?
Liver
Bone
Thymus
Secondary lymphoid organs?
Spleen
Lymph nodes
What is an immunologic chimera?
2 different cell lines in one individual
What does IL-2 do (oncologic treatment)?
Converts lymphocytes to lymphokine-activated killer cells by enhancing immune response to tumor
Converts lymphocytes into tumor-infiltrating lymphocytes
Has shown some success for melanoma
Tetanus prophylaxis
Tetanus toxoid only if non-tetanus prone wound if < 3 doses or status unknown
Always give toxoid if tetanus-prone wound unless pt is immunized
Immune globulin if tetanus-prone wound and pt not immunized or status unknown
Author
khata
ID
280189
Card Set
ABSITE Ch 4: Immunology
Description
Absite review chapter 4: Immunology
Updated
8/4/2014, 12:18:00 AM
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