Specific Org Groups and Their Tx

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  1. GPC: Staphylococci and Streptococci
    The Best intial Tx for G(+) orgs are:
    • Oxacillin, cloxacillin, dicloxacillin, nafcillin
    • 1st gen ceph: Cefazolin, cephalexin
    • Fluoroquinolones
    • Macrolides-- are 3rd line bc < efficacy than oxacillin or ceph...
    • - Erythromycin is also > toxic
  2. Oxacillin (Methicillin)-Resistant Staphylococcus
    best tx with:
    • Vancomycin
    • Linezolid: :( reversible BM-toxicity
    • Daptomycin: :( elevated CPK
    • Tigecycline
    • Ceftaroline
  3. Minor MRSA skin infxn
    Tx w:
    • TMP/SMX
    • Clindamycin
    • Doxycycline
    • Linezolid
  4. Anaerobes Tx w:
    • Oral (above diaphragm)
    • - PCN (G, VK, ampicillin, amoxicillin)
    • - Clindamycin
    • ABD/GI (below diaphragm)
    • - Metronidazole, beta-lactam/lactamase combo
  5. GNB
    (E. coli, Kleb, Proteus, Pseudomonas, Enterobacter, Citrobacter)
    Infxn of bowel (peritonitis, diverticulitis); UTI (pyelonephritis); and liver (cholecystitis, cholangitis)
    • Quinolones
    • Aminoglycosides
    • Carbapenems
    • Piperacillin, ticarcillin
    • Aztreonam
    • Cephalosporins
  6. A man is admitted with E. coli bacteremia.  What is the most appropriate therapy?
    • choice of
    • quinolones, aminoglycoside, carbapenem, piperacillin, ticarcillin, or aztreonam
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Specific Org Groups and Their Tx
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