cancer drugs

Card Set Information

cancer drugs
2014-08-16 14:56:29

cancer drugs for Level 4
Show Answers:

  1. Chlorambucil-leukeran
    • Alkylating agent
    • Indications- palliative treatment of chronic lymphocytic leukemia, malignant lymphomas and Hodgkin disease.
    • Actions: alkylates cellular DNA, interfering with the replication of susceptible cells.
    • Adverse effects: tremors, muscle twitching, confusion, nausea, hepatotoxicity, bone marrow suppression, sterility, cancer.
  2. Methotrexate
    • Antimetabolite
    • treats gestational choriocarcinoma, hydatidiform, meningeal leukemia; symptomatic control of severe psoriasis; rheumatoid arthritis; juvenile rheumatoid arthritis.
    • Actions: inhibits folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication; affects the most rapidly dividing cells.
    • Adverse effects: fatigue, malaise, rashes, alopecia, ulcerative stomatitis, hepatic toxicity, severe bone marrow suppression, interstitial pneumonitits, chill, fever, anaphylaxis.
  3. Doxorubicin-Adriamycin
    • Antineoplastic antibiotics
    • Indications: to produce regression in leukemias, lymphomas, Wilm's tumor, and Kaposi's sarcoma.
    • Pharm: IV route, rapid onset, peaks in 2 hours, with a duration of 24-36 hours, metabolized in liver and excreted in bile, feces, and urine.
    • Actions: binds to DNA and inhibits DNA synthesis in susceptible cells, causing cell death.
    • Adverse effects: cardiac toxicity, alopecia, NV, mucositis, red urine, myelosupression, fever, chills, rash.
  4. Vincristine- oncovin/vincasar
    • Mitotic inhibitors
    • Indications: acute leukemias, Hodgkin's disease, non-Hodgkins lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilm's tumor.
    • Actions: interferes with the cells ability to divide.

    • Pharm: IV route, has variable onset/peak, 15-30 min. , metabolized in liver and excreted in feces and urine
    • Adverse effects: BMS, GI effects, renal/hepatic dysfunction and alopecia
  5. Tamoxifen-Nalvadex
    • Hormones and hormone modulators
    • Indications: treatment of metastatic breast cancer
    • Action: competes with estrogen for binding sites in target tissues, such as the breast: a potent antiestrogenic agent.
    • Adverse¬†effects: hot flashes, rash, NV, vaginal bleeding, menstrual irregularities, moodiness, depression, vaginal dryness, edema, pain,¬†cva, pulmonary emboli
    • Pharm: oral route