- Mitotic inhibitors
- Indications: acute leukemias, Hodgkin's disease, non-Hodgkins lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilm's tumor.
- Actions: interferes with the cells ability to divide.
- Pharm: IV route, has variable onset/peak, 15-30 min. , metabolized in liver and excreted in feces and urine
- Adverse effects: BMS, GI effects, renal/hepatic dysfunction and alopecia