PHRD6085 Pharmacotherapy Lecture 1 - Cardiovascular Overview

Card Set Information

Author:
daynuhmay
ID:
281245
Filename:
PHRD6085 Pharmacotherapy Lecture 1 - Cardiovascular Overview
Updated:
2014-08-25 03:57:54
Tags:
Cardiovascular
Folders:

Description:
Cardiovascular
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user daynuhmay on FreezingBlue Flashcards. What would you like to do?


  1. circulation that pumps blood through the lungs
    pulmonary circulation
  2. flow of pulmonary circulation
    R ventricle -> pulmonary artery -> lungs -> pulmonary vein -> left ventricle
  3. circulation that pumps blood to organs and tissues
    systemic circulation
  4. flow of systemic circulation
    L ventricle -> aorta -> organs/tissues -> R atrium (via superior or inferior vena cava)
  5. valve between R atrium & R ventricle
    tricuspid valve
  6. valve between L atrium & L ventricle
    mitral valve
  7. valve between R ventricle & pulmonary artery
    pulmonary valve
  8. valve between L ventricle & aorta
    aortic valve
  9. valves open during diastole
    • tricuspid
    • mitral
  10. valves open during systole
    • pulmonary
    • aortic
  11. 5 effects of an activated RAAS system
    • 1) inc aldosterone synthesis
    • 2) sodium/water reabsorption
    • 3) vasoconstriction
    • 4) inc PVR
    • 5) inc CO
  12. converts angiotensinogen into angiotensin I
    renin
  13. converts angiotensin I into angiotensin II
    ACE
  14. negative consequences of aldosterone on the heart (3)
    • 1) myocardial fibrosis
    • 2) ventricular arrhythmias
    • 3) left ventricular hypertrophy (LVH)
  15. pressure stretching the ventricle of the heart after atrial contraction and subsequent passive filling of the ventricle; end diastolic volume
    preload
  16. tension/pressure used by the chamber of the heart in order to contract and eject blood out of the chamber; end systolic volume
    afterload
  17. end diastolic V - end systolic V
    stroke volume (SV)
  18. amount of blood pumped per unit of time (HR*SV)
    cardiac output (CO)
  19. CO adjusted for BSA (CO/BSA)
    cardiac index (CI)
  20. fraction of blood ejected by the left ventricle during contraction or ejection phase of cardiac cycle (SV/EDV * 100%)
    ejection fraction (EF)
  21. (CO x systemic vascular resistance) + central venous pressure
    OR...
    [(2 x diastolic P)+systolic P]/3
    mean arterial pressure (MAP)
  22. (under most circumstances) provides an accurate estimate of the diastolic filling (preload) of the left heart;
    during diastole when mitral valve is open, reflects left ventricular end-diastolic volume (preload)
    pulmonary capillary wedge pressure (PCWP)
  23. LVEDP
    left ventricular end-diastolic preload
  24. clinical findings suggestive of increased preload (7)
    • 1) hepatomegaly
    • 2) jugular venous distension
    • 3) peripheral edema
    • 4) pulmonary crackles
    • 5) S3 heart sound
    • 6) mucous membranes & skin turgor
    • 7) daily weight
  25. clinical findings suggestive of increased afterload (3)
    • 1) vascular diastolic pressure
    • 2) wide pulse pressure
    • 3) pulses
  26. pathophysiology of artherosclerosis
    formation of atheroma in arterial walls leading to hardening of the arteries
  27. pathophysiology of ischemic heart disease (IHD)
    lack of oxygen tension results in loss of high energy phosphates due to disruption of aerobic metabolism
  28. 4 steps in the development of atherosclerosis
    • 1) endothelial dysfunction
    • 2) fatty streak formation
    • 3) fibrous plaque formation
    • 4) thrombus formation
  29. causes/risk factors of endothelial dysfunction (9)
    • 1) age
    • 2) sex (M>F)
    • 3) smoking
    • 4) family hx of CHD
    • 5) dyslipidemia
    • 6) obesity
    • 7) diabetes
    • 8) hypertension
    • 9) inc homocysteine
  30. effect of myocardial remodeling on ventricles (3)
    • increased P
    • increased r
    • decreased wall thickness

What would you like to do?

Home > Flashcards > Print Preview