skin

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Author:
rere_girl4ever
ID:
281364
Filename:
skin
Updated:
2014-08-26 21:26:26
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skin usmle
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skin usmle
Description:
skin usmle
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  1. What is this type of skin disorder?
    Marker?
    What could cause this skin disease?
    Superficial spreading melanoma- MC, horizontal growth

    S-100 marker

    • Sunlight exposure
    • Mutation in BRAF kinase
  2. What is this type of skin disorder?
    Marker?
    What could cause this skin disease?

    Nodular melanoma- vertical growth, worse prognosis

    S-100 marker

    • Sunlight exposure
    • Mutation in BRAF kinase
  3. What is this type of skin disorder?
    Marker?
    What could cause this skin disease?
    Nodular melanoma- vertical growth, worst prognosis

    S-100 marker

    • Sunlight exposure
    • Mutation in BRAF kinase
  4. What is this type of skin disorder?
    Marker?
    What could cause this skin disease?

    Lentigo maligna melanoma- usually on face and neck of older individuals. Has the best prognosis.

    S-100 marker

    • Sunlight exposure
    • Mutation in BRAF kinase
  5. What is this type of skin disorder?
    Marker?
    What could cause this skin disease?

    Lentigo maligna melanoma

    S-100 marker

    • Sunlight exposure
    • Mutation in BRAF kinase
    • Acrolentiginous melanoma- most common in dark skinned individuals. Affects palms, soles.
    • S-100 marker

    • Sunlight exposure
    • Mutation in BRAF kinase
  6. Acrolentiginous melanoma- most common in dark skinned individuals. Affects palms, soles.

    S-100 marker

    • Sunlight exposure
    • Mutation in BRAF kinase
  7. Patients with this skin disorder are at risk for developing?
    What are the genetics of this skin disorder?

    Dysplastic nevus syndrome

    At risk for malignant melanoma

    Autosomal dominant (CMM1 gene on chromosome 1)
  8. This skin disease is associated with loss of function mutation of the p16 tumor suppressor gene on chromosome 9.
    Familial melanoma
  9. What is the most significant factor for long term prognosis for melanoma?
    Depth of the lesion- Lymphatics of the superficial dermis lie 1mm under the skin surface.
  10. Hydrocarbons and arsenic exposure are commonly associated with what skin disease?
    Squamous cell carcinoma
  11. What type of skin disorder is displayed in this picture?
    Patients with this skin disorder are at risk of developing which disease?

    Xeroderma pigmentosum

    Squamous cell carcinoma
  12. What type of skin disorder is this?
    Patients are at risk for developing?

    Actinic Keratosis- sun induced dysplasia of keratonocytes that causes a scaly plaque.

    At risk for squamous cell carcinoma
  13. What type of skin disease is this?
    Patients are at risk for developing?

    Keratoancanthoma- rapidly growing dome shaped nodules with a central keratin filled crater

    Squamous cell carcinoma
  14. This microscopic finding presented below is a finding of which disease?
    Keratin pearls- Squamous cell carcinoma

    Microscopic examination shows nests of atypical keratinocytes that invade the dermis, formation of keratin pearls and intracellular bridges (desmosomes) between tumor cells.
  15. What is this skin disease?

    Patients with this skin disease are at risk for?
    Bowen disease (squamous cell carcinoma in situ)

    These abnormal cell grow in their normal place thus "in situ."

    Bowen disease is the accumulation of dysplastic epidermal cells within the epidermis only, that has failed to penetrate into the deeper dermis.
  16. Microscopic findings reveals invasive nests of basaloid cells with "palisading nuclei" in this skin disease.
    Basal cell carcinoma
  17. Pink, pearly nodules, commonly with telangiectasias, rolled borders, and central crusting or ulceration.
    Basal cell carcinoma
  18. The skin disorder in these pictures are a finding of?

    Lichen planus

    • Pruritic 
    • Purple
    • Polyglonal
    • Planar 
    • Papules
  19. Patient presents with pruritic, purple, polyglonal, planar papules and plaques. The disease progresses to the mucosa forming reticular white lines.
    Lichen planus

    Mucosal involvement manifests as Wickham striae (reticular white lines)

    Pruritic Purple Polyglonal Planar Papules
  20. Microscopic findings of this skin disease is a sawtooth infiltrate of lymphocytes at dermal-epidermal junction.
    Lichen planus

    Pruritic Purple Polyglonal Planar Papules

    Mucosal involvement manifests as Wickham striae (reticular white lines)
  21. Skin disorder associated with hepatitis C.
    Lichen planus
  22. Itchy (pruritic) rash that starts with an oval shaped patch and progresses to a papular eruption of the trunk to produce a "Christmas tree distribution."
    • Herald patch- oval shaped patch
    • Pitryasis rosea
  23. Itchy rash that presents with multiple plaques with collateral scale, often following a "Chistmas tree" distribution.
    Pitryasis rosea

    Herald patch- pink oval patch

    Resolves in 6-8 weeks
  24. This skin disorder causes DNA mutations, inducing apoptosis of keratinocytes.
    Sunburn
  25. Sunburn is an acute cutaneous inflammatory reaction due to excessive UV radiation. What type of UV light plays a role in sunburn?
    • UVB--> sunburn
    • UVA--> tanning and photoaging
  26. Which skin disorders can sunburn manifest into?
    • 1. Impetigo (honey crusted lesions)
    • 2. Skin cancers (basal cell carcinoma, squamous cell carcinoma, and melanoma).
  27. In this skin disorder, there is epidermal hyperplasia causing symmetrical, hyperpigmented, velvety thickening of skin, especially on neck or in axilla.  Which other diseases is this skin disorder associated with? 
    Acanthosis nigricans

    • Associated with:
    • Hyperinsulinemia (diabetes, obesity, Cushing syndrome)
    • Viscerral malignancy (gastric adenocarcinoma)
  28. This picture demonstrates soft, tan-colored, cauliflower-like papules. In which disease is this skin disorder found?

    Verrucae- warts, caused by HPV

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