skin

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rere_girl4ever
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281386
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skin
Updated:
2014-08-26 21:18:49
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  1. This skin disorder is associated with celiac disease.
    Dermatitis herpetiformis
  2. Deposits of IgA at the tips of dermal papillae is associated with which disease?
    • Dermatitis herpetiformis
    • Asssociated with celiac disease
  3. This skin disorder presents as itchy/pruritic papules, vesicles, and bullae (often found on elbows). Deposits of IgA are found at the tips of dermal papillae.

    • Dermatitis herpetiformis
    • Associated with celiac disease
  4. This skin disorder is described as tense blisters containing eosinohils which affect the skin but spare oral mucosa. 

    Bullous pemphigoid
  5. IgG antibody against hemidesmosomes is found in which skin disease?
    Bullous pemphigoid
  6. This skin disorder is described as tense blisters containing eosinohils which affect the skin but spare oral mucosa
    Bullous pemphigoid
  7. Immunofluorecence of this skin disorder reveals linear pattern at epidermal-dermal junction.

    .
    Bullous pemphigoid
  8. This is a potentially fatal autoimmune skin disorder with IgG antibody against desmoglein 3 (component of desmosomes) with resulting loss of intracellular adhesion.
    Pemphigus vulgaris
  9. In this skin disease, immunofluorescence reveals antibodies around epidermal cells in a reticular (net-like) pattern.

    Pemphigus vulgaris
  10. This skin disorder has a positive Nikolsky sign (separation of epidermis upon manual stroking of skin).
    Pemphigus vulgariseasily ruptured flaccid blisters

    Nikolsky sign is negative Bullous Pemphigus
  11. Microscopic examination shows intraepidermal acantholysis which leaves behind a basal layer of keratinocytes which has a tombstone-like appearance.
    Pemphigus vulgaris
  12. This skin disorder is a more severe form of Stevens-Johnson syndrome where the epidermal-dermal junction is destroyed.

    A more severe form of Stevens-Johnson syndrome with > 30% of the body surface area involved is toxic epidermal necrolysis
  13. Steven Johnson syndrome

    Characterized by fever, bulla formation and necrosis, sloughing of skin, and a high mortality rate.

    Typically 2 mucous membranes are involved  and skin lesions may appear like targets as seen in erythema multiforme. Usually associated with adverse drug reaction.
  14. Which diseases/ drugs are associated with erythema nodosum/ multiforme. Place them under the appropriate pictures
  15. Painful inflammatory lesions of subcutaneous fat, usually on anterior shins. 

    Erythema nodosum
  16. Presents with multiple types of lesions—macules, papules, vesicles, and target lesions (look like targets with multiple rings and a dusky center showing epithelial disruption)

    Erythema multiforme
  17. Honey colored crusting with bullae.

    Bullous impetigo has bullae and is usually caused by S. aureus
  18. Honey colored crusting

    Impetigo- s.aureus, s.pyogenes
  19. Acute, painful, spreading infection of dermis and subcutaneous tissues

    Cellulitis- S.pyogenes, S.aureus
  20. Deeper tissue injury,which results in crepitus from methane and CO2production. Causes bullae and a purple color to the skin
    Necrotizing fasciitis- usually S.pyogenes
  21. In this skin disortder, xxotoxin destroys keratinocyte attachments in the stratum granulosum only. Characterized by fever and generalized erythematous rash with sloughing of the upper layers of the epidermis that heals completely. Seen in newborns and children
    Staphylococcal scalded skin syndrome
  22. This disease presents with white, painless plaques on the tongue that cannot be scraped off.

    In which patients is this disease common and what could cause it?
    Hairy Leukoplakia.

    EBV mediated. Occurs in HIV-positive patients
  23. Intradermal nevus- papular
  24. Junctional nevus- flat macules
  25. This skin disorder is described as pruritic wheals that form after mast cell degranulation. Characterized by superficial dermal edema and lymphatic channel dilation.

    Hives/ Urticaria
  26. In this disorder, is the number of melanocytes increased or is the pigment increased?

    Ephelis.

    Freckle. Normal number of melanocytes, increased melanin pigment
  27. Papules and plaques with silvery scaling, especially on knees and elbows.

    Psoriasis
  28. In this skin disorder,  pinpoint bleeding spots occur from exposure of dermal papillae when scales are scraped off.- 

    Auspitz signPsoriasis
  29. Skin disease associated with pitting nails.

    Psoriasis
  30. Acanthosis with parakeratotic scaling (nuclei still in stratum corneum). Increased stratum spinosum, decreased stratum granulosum. 

    Psoriasis
  31. Sudden appearance of multiple flat, greasy keratin-filled cysts (horn cysts). What skin disorder is this and what may it indicate?
    Leser-Trélat sign—sudden appearance of multiple seborrheic keratoses, indicating an underlying malignancy (e.g., GI, lymphoid).
  32. Type IV hypersensitivity reaction that follows exposure to allergen. Lesions occur at site of contact (e.g., nickel, poison ivy, neomycin)
    Allergic contact dermatitis
  33. Pruritic eruption, commonly on skin flexures. Often associated with other atopic diseases (asthma, allergic rhinitis). Usually starts on the face in infancy and often appears in the antecubital fossae thereafter.
    Atopic dermatitis (eczema)
  34. In this skin disorder, there is increased thickness of the stratum corneum.
    • HYPERKERATOSIS
    • Psoriasis, calluses
  35. In this skin disorder, there is hyperkeratosis with retention of nuclei in stratum corneum.
    • PARAKERATOSIS
    • Psoriasis
  36. This skin disorder is characterized by SpongiosisEpidermal accumulation of edematous fluid in intercellular spaces
    Eczematous dermatitis
  37. This skin disorder is characterized by Acantholysis- Separation of epidermal cells
    Pemphigus vulgaris
  38. This skin disorder is characterized by Acanthosis- epidermal hyperplasia (spinosum)
    Acanthosis nigricans
  39. What disorder is this and what causes it?

    Albinism

    Normal melanocyte number with decreased melanin production due to:

    1. Decreased tyrosinase activity or defective tyrosine transport.

    2.Failure of neural crest cell migration during development.
  40. Puffy and taut skin with absence of wrinkles.
    Scleroderma
  41. Disease associated with anti-Scl-70 antibody.
    • Diffuse scleroderma 
    •  
    • Associated with anti Scl-70 antibody (anti-DNA topoisomerase I antibody)
  42. Disease associated with anti-DNA topoisomerase I antibody.
    Diffuse scleroderma

    Associated with anti Scl-70 antibody (anti-DNA topoisomerase I antibody)

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