Biochemical Foundations of Physiology -3 Part
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Where does the TCA Cycle occur ?
Is it a aerobic or anaerobic process ?
Occurs totally in the mitochondria and is therefore in close proximity to the reactions of the ETC
Before the cycle begins pyruvate is converted to acetyl CoA by what complex ?
pyruvate dehydrogenase complex
What makes up the pyruvate dehydrogenase
complex ? Each catalyze part of the overall reaction
- 1.Pyruvate dehydrogenase (E1)
- 2.Dihydrolipoyl transacetylase (E2)
- 3.Dihydrolipoyl dehydrogenase (E3)
How many coenzymes does PDH have ?
What are the coenzymes for PDH ?
1.Pyruvate dehydrogenase (E1)
2.Dihydrolipoyl transacetylase (E2)
3.Dihydrolipoyl dehydrogenase (E3)
- E1 requires Thiamine pyrophosphate (TPP)
- E2 requires Lipoic acid and CoA
- E3 requires FAD and NAD+
Arsenic poisoning is due primarily to inhibition of enzymes that require what coenzyme ?
A deficiency of Pyruvate dehydrogenase (E1) will cause what ?
The inability to convert pyruvate to acetyl CoA will make ?
congenital lactic acidosis
What are the NADH producing step in the TCA cycle ?
What are the FADH producing steps in the TCA cycle ?
What are the GTP producing step in the TCA cycle ?
The condensation of acetyl CoA and oxaloacetate to form citrate is catalyzed by what enzyme ?
Citrate is isomerized to isocitrate by what enzyme ?
What enzyme catalyzes the irreversible oxidative decarboxylation of isocitrate to form α-ketoglutarate ?
The conversion of α-ketoglutarate to succinyl CoA is catalyzed by what enzyme ?
α-ketoglutarate dehydrogenase complex.
The cleavage of succinyl CoA to form succinate is catalyzed by the what
succinyl CoA synthetase
Succinate is oxidized to fumarate by what enzyme ?
What is the only enzyme of the TCA cycle
that is embedded in the inner mitochondrial membrane ?
Fumarate is hydrated to malate by what enzyme ?
Malate is oxidized to oxaloacetate by what enzyme ?
The most important of TCA's
these regulated enzymes are those that catalyze reactions with highly negative ∆Go: Which are they ?
- 1.Citrate synthase
- 2.Isocitrate dehydrogenase
- 3.α-ketoglutarate dehydrogenase complex
What is the gross and net production of ATP for glycolysis ?
Where is gluconeogensis taking place overnight ?
What about a prolonged fast ?
90% liver and 10% Kidneys
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